Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu mutation
(0 available);
any
Dhx9 mutation
(76 available)
Igs12tm1Zhu mutation
(0 available);
any
Igs12 mutation
(0 available)
Ptprca mutation
(51 available);
any
Ptprc mutation
(188 available)
Ptprcb mutation
(8 available);
any
Ptprc mutation
(188 available)
Tg(Lck-cre)#Zhu mutation
(0 available)
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immune system
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• stage-specific alterations in T cell maturation determined by the ratio of Ptprca to Ptprcb expressing cells
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hematopoietic system
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• stage-specific alterations in T cell maturation determined by the ratio of Ptprca to Ptprcb expressing cells
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hematopoietic system
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• although lytic activity of NK cells is normal, fewer granzyme B positive NK cells are found after treatment with interleukin 15
• there is an increase in interferon gamma positive NK cells compared with controls after treatment with interleukin 12 plus 18, or anti-NK1.1 antibodies, and there is a significant increase in interferon gamma secretion by NK cells treated with anti-Ly49H antibodies for 6 hours
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immune system
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• although lytic activity of NK cells is normal, fewer granzyme B positive NK cells are found after treatment with interleukin 15
• there is an increase in interferon gamma positive NK cells compared with controls after treatment with interleukin 12 plus 18, or anti-NK1.1 antibodies, and there is a significant increase in interferon gamma secretion by NK cells treated with anti-Ly49H antibodies for 6 hours
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• increased NK cell interferon production in both liver and spleen after murine cytomegalovirus infection
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• although there is no difference in susceptibility to C rodentium bacterial infection, the Ncr1 point mutation causes altered response to viral infection
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• increased survival after influenza A infection compared with controls
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• Increased resistance to murine cytomegalovirus Smith strain compared with controls
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homeostasis/metabolism
mortality/aging
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• although there is no difference in susceptibility to C rodentium bacterial infection, the Ncr1 point mutation causes altered response to viral infection
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• increased survival after influenza A infection compared with controls
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• Increased resistance to murine cytomegalovirus Smith strain compared with controls
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