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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cxcl5tm1Gscw
targeted mutation 1, G Scoot Worthen
MGI:4819800
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cxcl5tm1Gscw/Cxcl5tm1Gscw involves: 129 MGI:4819816
cx2
Cxcl5tm1Gscw/Cxcl5tm1Gscw
Ackr1tm1Scp/Ackr1tm1Scp
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:4819818


Genotype
MGI:4819816
hm1
Allelic
Composition
Cxcl5tm1Gscw/Cxcl5tm1Gscw
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl5tm1Gscw mutation (0 available); any Cxcl5 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in an E. coli model of pneumonia, mice exhibit fewer bacteria in the lungs, increased neutrophil infiltration in the lungs, reduced lung wet/dry weight at 24 hours post-infection, decreased edema, and reduced mortality compared with similarly treated wild-type mice

immune system
• mice exhibit increased Gr1+ and Gr1+ CXCR2+ cells in the bone marrow compared with wild-type mice
• however, the number of neutrophils in the blood is normal
• in LPS or E. coli models of pneumonia, initial neutrophil influx into the lungs is enhanced but declines more rapidly than in similarly treated wild-type mice
• following intatracheal E. coli challenge, mice exhibit reduced CXCL1 and CXCL2 plasma levels while bronchoalveolar fluid levels are increased compared with similarly treated wild-type mice
• after injection with recombinant CXCL1, CXCL2, and CXCL5, mice exhibit attenuated plasma concentrations of these chemokines compared with similarly treated wild-type mice
• after injection with CXCL1, the amount of plasma CXCL1 is decreased with the amount of erythrocyte-binding CXCL1 is increased compared to in wild-type mice
• in response to inhaled LPS, mice exhibit attenuated CXCL1 levels in the plasma compared with similarly treated wild-type mice
• mice exhibit improved chemokine scavenging compared with wild-type mice
• 6 hours after intatracheal E. coli challenge
• however, levels are normal at 24 hours post infection
• in response to inhaled LPS, mice exhibit attenuated neutrophil infiltration, TNFalpha and IL6 levels in the bronchoalvealoar fluid, and CXCL1 in the plasma compared with similarly treated wild-type mice
• in an E. coli model of pneumonia
• in an E. coli model of pneumonia, mice exhibit fewer bacteria in the lungs, increased neutrophil infiltration in the lungs, reduced lung wet/dry weight at 24 hours post-infection, decreased edema, and reduced mortality compared with similarly treated wild-type mice

homeostasis/metabolism
• following intatracheal E. coli challenge, mice exhibit reduced CXCL1 and CXCL2 plasma levels while bronchoalveolar fluid levels are increased compared with similarly treated wild-type mice
• after injection with recombinant CXCL1, CXCL2, and CXCL5, mice exhibit attenuated plasma concentrations of these chemokines compared with similarly treated wild-type mice
• after injection with CXCL1, the amount of plasma CXCL1 is decreased with the amount of erythrocyte-binding CXCL1 is increased compared to in wild-type mice
• in response to inhaled LPS, mice exhibit attenuated CXCL1 levels in the plasma compared with similarly treated wild-type mice
• mice exhibit improved chemokine scavenging compared with wild-type mice
• 6 hours after intatracheal E. coli challenge
• however, levels are normal at 24 hours post infection

hematopoietic system
• mice exhibit increased Gr1+ and Gr1+ CXCR2+ cells in the bone marrow compared with wild-type mice
• however, the number of neutrophils in the blood is normal
• in LPS or E. coli models of pneumonia, initial neutrophil influx into the lungs is enhanced but declines more rapidly than in similarly treated wild-type mice




Genotype
MGI:4819818
cx2
Allelic
Composition
Cxcl5tm1Gscw/Cxcl5tm1Gscw
Ackr1tm1Scp/Ackr1tm1Scp
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr1tm1Scp mutation (1 available); any Ackr1 mutation (12 available)
Cxcl5tm1Gscw mutation (0 available); any Cxcl5 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit increased chemokine scavenging compared with wild-type mice although not as severe as in Darctm1Scp homozygotes

immune system
• mice exhibit increased chemokine scavenging compared with wild-type mice although not as severe as in Darctm1Scp homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory