Mouse Genome Informatics
tg1
    Tg(Myh6-TNNT2*R141W)#Ajm/0
involves: C3H * C57BL/6 * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• 29% of mice die within 1 year and almost all die by 2 years of age

cardiovascular system
• increase in the ventricular weight to body weight ratio compared to age and sex matched controls
• increase in expression of markers of cardiac hypertrophy
• increase in left ventricular end systolic and end diastolic diameters
• increase in the collagen volume fraction
• decrease in left ventricular systolic function

homeostasis/metabolism
• increase in the collagen volume fraction

Mouse Models of Human Disease
OMIM IDRef(s)
Cardiomyopathy, Dilated, 1D; CMD1D 601494 J:161899