mortality/aging

premature death ( J:161899 )

• 29% of mice die within 1 year and almost all die by 2 years of age

cardiovascular system

enlarged heart ( J:161899 )

increased heart weight ( J:161899 )

• increase in the ventricular weight to body weight ratio compared to age and sex matched controls

increased left ventricle weight ( J:161899 )

cardiac hypertrophy ( J:161899 )

• increase in expression of markers of cardiac hypertrophy

• increase in left ventricular end systolic and end diastolic diameters

cardiac interstitial fibrosis ( J:161899 )

• increase in the collagen volume fraction

• decrease in left ventricular systolic function

Mouse Models of Human Disease		OMIM ID	Ref(s)
Cardiomyopathy, Dilated, 1D; CMD1D		601494	J:161899