Mouse Genome Informatics
tg1
    Tg(Tnnt2-TNNT2*R92Q)M-2Ajm/0
involves: C3H * C57BL/6 * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• cardiomyocyte disarray
• this line displays the most extensive disarray relative to other lines carrying the same transgene
• increase in interstitial collagen
• the decrease in the ratio of peak early velocity to peak atrial velocity is indicative of left ventricular diastolic dysfunction
• increase in mitral valve peak atrial velocity and a decrease in the ratio of peak early velocity to peak atrial velocity compared to controls

muscle
• cardiomyocyte disarray
• this line displays the most extensive disarray relative to other lines carrying the same transgene

Mouse Models of Human Disease
OMIM IDRef(s)
Cardiomyopathy, Familial Hypertrophic, 2; CMH2 115195 J:117554