Mouse Genome Informatics
cx1
    Tg(Lck-LMO1)11Sjk/0
Tg(STIL-TAL1)A5(3)Alpa/0

involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• lymphoblasts replace bone marrow

tumorigenesis
• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months
• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

behavior/neurological

liver/biliary system

respiratory system

immune system
• peripheral
• mice exhibit widespread organ infiltration including liver, kidney, lung, and bone marrow

endocrine/exocrine glands

Mouse Models of Human Disease
OMIM IDRef(s)
Leukemia, Acute Lymphoblastic; ALL 613065 J:40868


Mouse Genome Informatics
tg2
    Tg(Lck-LMO1)11Sjk/0
involves: C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
N
• mice do not develop T cell malignancy by 6 months of age (J:40868)