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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lck-LMO1)11Sjk
transgene insertion 11, Stanley J Korsmeyer
MGI:4819166
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ccnctm1.1Pisc/Ccnctm1.1Pisc
Tg(Lck-LMO1)11Sjk/0
Tg(Mx1-cre)1Cgn/0
Not Specified MGI:5697722
cx2
Tg(Lck-LMO1)11Sjk/0
Tg(STIL-TAL1)A5(3)Alpa/0
involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros MGI:4819172
tg3
Tg(Lck-LMO1)11Sjk/0 involves: C3H * C57BL/6 MGI:4819174


Genotype
MGI:5697722
cn1
Allelic
Composition
Ccnctm1.1Pisc/Ccnctm1.1Pisc
Tg(Lck-LMO1)11Sjk/0
Tg(Mx1-cre)1Cgn/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnctm1.1Pisc mutation (0 available); any Ccnc mutation (15 available)
Tg(Lck-LMO1)11Sjk mutation (0 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors

tumorigenesis
• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors




Genotype
MGI:4819172
cx2
Allelic
Composition
Tg(Lck-LMO1)11Sjk/0
Tg(STIL-TAL1)A5(3)Alpa/0
Genetic
Background
involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• lymphoblasts replace bone marrow

tumorigenesis
• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months
• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

behavior/neurological

liver/biliary system

respiratory system

immune system
• peripheral
• mice exhibit widespread organ infiltration including liver, kidney, lung, and bone marrow

endocrine/exocrine glands
• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Acute Lymphoblastic; ALL 613065 J:40868




Genotype
MGI:4819174
tg3
Allelic
Composition
Tg(Lck-LMO1)11Sjk/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
N
• mice do not develop T cell malignancy by 6 months of age





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory