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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(STIL-TAL1)A5(3)Alpa
transgene insertion A5(3), Peter Alpan
MGI:4819165
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Lck-LMO1)11Sjk/0
Tg(STIL-TAL1)A5(3)Alpa/0
involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros MGI:4819172
tg2
Tg(STIL-TAL1)A5(3)Alpa/0 involves: C3H/HeRos * C57BL/10Ros MGI:4819173


Genotype
MGI:4819172
cx1
Allelic
Composition
Tg(Lck-LMO1)11Sjk/0
Tg(STIL-TAL1)A5(3)Alpa/0
Genetic
Background
involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• lymphoblasts replace bone marrow

neoplasm
• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months
• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

behavior/neurological

liver/biliary system

respiratory system

immune system
• peripheral
• mice exhibit widespread organ infiltration including liver, kidney, lung, and bone marrow

endocrine/exocrine glands
• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Acute Lymphoblastic; ALL 613065 J:40868




Genotype
MGI:4819173
tg2
Allelic
Composition
Tg(STIL-TAL1)A5(3)Alpa/0
Genetic
Background
involves: C3H/HeRos * C57BL/10Ros
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice do not develop T cell malignancy by 6 months of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory