hematopoietic system

decreased erythrocyte cell number ( J:40868 )

increased leukocyte cell number ( J:40868 )

• in some mice

decreased platelet cell number ( J:40868 )

decreased bone marrow cell number ( J:40868 )

• lymphoblasts replace bone marrow

enlarged spleen ( J:40868 )

enlarged thymus ( J:40868 )

tumorigenesis

T cell derived lymphoma ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

leukemia ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

behavior/neurological

lethargy ( J:40868 )

liver/biliary system

enlarged liver ( J:40868 )

respiratory system

respiratory distress ( J:40868 )

immune system

increased leukocyte cell number ( J:40868 )

• in some mice

enlarged spleen ( J:40868 )

enlarged thymus ( J:40868 )

enlarged lymph nodes ( J:40868 )

• peripheral

abnormal inflammatory response ( J:40868 )

• mice exhibit widespread organ infiltration including liver, kidney, lung, and bone marrow

Mouse Models of Human Disease		OMIM ID	Ref(s)
Leukemia, Acute Lymphoblastic; ALL		613065	J:40868