Mouse Genome Informatics
cx1
    Ightm1(Myc)Janz/Igh+
Tg(Emu-FGFR3)D3Wmk/0

involves: 129X1/SvJ * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• tumors are less differentiated than tumors from Ightm1(Myc)Janz heterozygotes
• 98% of mice developed tumors at a median age of 156 days unlike wild-type mice
• 1 tumor exhibits plasmacytoid differentiation

Mouse Models of Human Disease
OMIM IDRef(s)
Myeloma, Multiple 254500 J:160845


Mouse Genome Informatics
tg2
    Tg(Emu-FGFR3)D3Wmk/0
FVB/N-Tg(Emu-FGFR3)D3Wmk
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• in 10 of 32 mice