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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Emu-FGFR3)D3Wmk
transgene insertion D3, W Michael Kuehl
MGI:4819001
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ightm1(Myc)Janz/Igh+
Tg(Emu-FGFR3)D3Wmk/0
involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:4819007
tg2
Tg(Emu-FGFR3)D3Wmk/0 FVB/N-Tg(Emu-FGFR3)D3Wmk MGI:4819005


Genotype
MGI:4819007
cx1
Allelic
Composition
Ightm1(Myc)Janz/Igh+
Tg(Emu-FGFR3)D3Wmk/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1(Myc)Janz mutation (2 available); any Igh mutation (35 available)
Tg(Emu-FGFR3)D3Wmk mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumors are less differentiated than tumors from Ightm1(Myc)Janz heterozygotes
• 98% of mice developed tumors at a median age of 156 days unlike wild-type mice
• 1 tumor exhibits plasmacytoid differentiation

Mouse Models of Human Disease
OMIM ID Ref(s)
Myeloma, Multiple 254500 J:160845




Genotype
MGI:4819005
tg2
Allelic
Composition
Tg(Emu-FGFR3)D3Wmk/0
Genetic
Background
FVB/N-Tg(Emu-FGFR3)D3Wmk
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in 10 of 32 mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory