Mouse Genome Informatics
hm1
    Jak2tm1.2Ble/Jak2tm1.2Ble
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• unable to obtain any viable homozygotes, with the stage of prenatal lethality not specified


Mouse Genome Informatics
ht2
    Jak2tm1.2Ble/Jak2+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• median survival is 146 days

tumorigenesis
• all develop a myeloproliferative neoplasm
• these myeloproliferative neoplasms can be transplanted by transfer of either unfractionated bone marrow cells or LSK cells but not by transfer of MEP or granulocyte/macrophage progenitor cells
• however, acute leukemia is not detected

hematopoietic system
N
• despite the increase in megakaryocyte numbers no increases in platelet counts are detected (J:160883)
• expansion of the megakaryocytic/erythroid progenitor (MEP) population
• disproportional increase in the number of erythroid progenitors relative to other myeloid progenitor
• increase in the number of erythroid precursors in the bone marrow and spleen
• marked erythroid hyperplasia in the splenic red pulp
• prominent splenic extramedullary hematopoiesis
• megakaryocytes with atypical nuclear features and prominent emperipolesis are present in the bone marrow
• mild hyperplasia in the splenic red pulp
• overall effacement of the normal architecture
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp
• MEPs show EPO hypersensitivity
• gene set enrichment analysis indicates that hematopoietic differentiation in the LSK compartment is altered

immune system
• overall effacement of the normal architecture
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp

Mouse Models of Human Disease
OMIM IDRef(s)
Polycythemia Vera; PV 263300 J:160883