About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Jak2tm1.2Ble
targeted mutation 1.2, Benjamin L Ebert
MGI:4818801
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Jak2tm1.2Ble/Jak2tm1.2Ble involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4818802
ht2
Jak2tm1.2Ble/Jak2+ involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4818803
cn3
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Vav1-icre)A2Kio/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640744
cn4
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Tg(Vav1-icre)A2Kio/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640746


Genotype
MGI:4818802
hm1
Allelic
Composition
Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• unable to obtain any viable homozygotes, with the stage of prenatal lethality not specified




Genotype
MGI:4818803
ht2
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 146 days

neoplasm
• all develop a myeloproliferative neoplasm
• these myeloproliferative neoplasms can be transplanted by transfer of either unfractionated bone marrow cells or LSK cells but not by transfer of MEP or granulocyte/macrophage progenitor cells
• however, acute leukemia is not detected

hematopoietic system
N
• despite the increase in megakaryocyte numbers no increases in platelet counts are detected
• expansion of the megakaryocytic/erythroid progenitor (MEP) population
• disproportional increase in the number of erythroid progenitors relative to other myeloid progenitor
• increase in the number of erythroid precursors in the bone marrow and spleen
• marked erythroid hyperplasia in the splenic red pulp
• prominent splenic extramedullary hematopoiesis
• megakaryocytes with atypical nuclear features and prominent emperipolesis are present in the bone marrow
• mild hyperplasia in the splenic red pulp
• overall effacement of the normal architecture
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp
• MEPs show EPO hypersensitivity
• gene set enrichment analysis indicates that hematopoietic differentiation in the LSK compartment is altered

immune system
• overall effacement of the normal architecture
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycythemia Vera; PV 263300 J:160883




Genotype
MGI:5640744
cn3
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (18 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (27 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• decreased numbers of mature erythrocytes
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells
• elevated reticulocyte counts

homeostasis/metabolism
• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type

immune system
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells




Genotype
MGI:5640746
cn4
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (18 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (27 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased red blood cell counts
• high hematocrit
• mild thrombocytosis
• elevated reticulocyte counts

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycythemia Vera; PV 263300 J:220728





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory