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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Jak2tm1.2Ble
targeted mutation 1.2, Benjamin L Ebert
MGI:4818801
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Jak2tm1.2Ble/Jak2tm1.2Ble involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4818802
ht2
Jak2tm1.2Ble/Jak2+ involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4818803
cn3
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Vav1-icre)A2Kio/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640744
cn4
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Tg(Vav1-icre)A2Kio/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640746


Genotype
MGI:4818802
hm1
Allelic
Composition
Jak2tm1.2Ble/Jak2tm1.2Ble
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• unable to obtain any viable homozygotes, with the stage of prenatal lethality not specified (J:160883)
• unable to obtain any viable homozygotes, with the stage of prenatal lethality not specified (J:160883)




Genotype
MGI:4818803
ht2
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 146 days (J:160883)
• median survival is 146 days (J:160883)

tumorigenesis
• all develop a myeloproliferative neoplasm (J:160883)
• these myeloproliferative neoplasms can be transplanted by transfer of either unfractionated bone marrow cells or LSK cells but not by transfer of MEP or granulocyte/macrophage progenitor cells (J:160883)
• however, acute leukemia is not detected (J:160883)
• all develop a myeloproliferative neoplasm (J:160883)
• these myeloproliferative neoplasms can be transplanted by transfer of either unfractionated bone marrow cells or LSK cells but not by transfer of MEP or granulocyte/macrophage progenitor cells (J:160883)
• however, acute leukemia is not detected (J:160883)

hematopoietic system
N
• despite the increase in megakaryocyte numbers no increases in platelet counts are detected (J:160883)
• despite the increase in megakaryocyte numbers no increases in platelet counts are detected (J:160883)
• expansion of the megakaryocytic/erythroid progenitor (MEP) population (J:160883)
• disproportional increase in the number of erythroid progenitors relative to other myeloid progenitor (J:160883)
• expansion of the megakaryocytic/erythroid progenitor (MEP) population (J:160883)
• disproportional increase in the number of erythroid progenitors relative to other myeloid progenitor (J:160883)
• increase in the number of erythroid precursors in the bone marrow and spleen (J:160883)
• marked erythroid hyperplasia in the splenic red pulp (J:160883)
• increase in the number of erythroid precursors in the bone marrow and spleen (J:160883)
• marked erythroid hyperplasia in the splenic red pulp (J:160883)
• prominent splenic extramedullary hematopoiesis (J:160883)
• prominent splenic extramedullary hematopoiesis (J:160883)
• megakaryocytes with atypical nuclear features and prominent emperipolesis are present in the bone marrow (J:160883)
• megakaryocytes with atypical nuclear features and prominent emperipolesis are present in the bone marrow (J:160883)
• mild hyperplasia in the splenic red pulp (J:160883)
• mild hyperplasia in the splenic red pulp (J:160883)
• overall effacement of the normal architecture (J:160883)
• overall effacement of the normal architecture (J:160883)
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp (J:160883)
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp (J:160883)
• MEPs show EPO hypersensitivity (J:160883)
• gene set enrichment analysis indicates that hematopoietic differentiation in the LSK compartment is altered (J:160883)
• MEPs show EPO hypersensitivity (J:160883)
• gene set enrichment analysis indicates that hematopoietic differentiation in the LSK compartment is altered (J:160883)

immune system
• overall effacement of the normal architecture (J:160883)
• overall effacement of the normal architecture (J:160883)
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp (J:160883)
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp (J:160883)

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycythemia Vera; PV 263300 J:160883




Genotype
MGI:5640744
cn3
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (5 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (15 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• decreased numbers of mature erythrocytes (J:220728)
• decreased numbers of mature erythrocytes (J:220728)
• decreased numbers of CD4+ T cells (J:220728)
• decreased numbers of CD4+ T cells (J:220728)
• decreased numbers of CD8+ T cells (J:220728)
• decreased numbers of CD8+ T cells (J:220728)
• elevated reticulocyte counts (J:220728)
• elevated reticulocyte counts (J:220728)

homeostasis/metabolism
• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type (J:220728)
• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type (J:220728)

immune system
• decreased numbers of CD4+ T cells (J:220728)
• decreased numbers of CD4+ T cells (J:220728)
• decreased numbers of CD8+ T cells (J:220728)
• decreased numbers of CD8+ T cells (J:220728)




Genotype
MGI:5640746
cn4
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (5 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (15 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased red blood cell counts (J:220728)
• increased red blood cell counts (J:220728)
• high hematocrit (J:220728)
• high hematocrit (J:220728)
• mild thrombocytosis (J:220728)
• mild thrombocytosis (J:220728)
• elevated reticulocyte counts (J:220728)
• elevated reticulocyte counts (J:220728)

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycythemia Vera; PV 263300 J:220728





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory