Phenotypes associated with this allele

• Allele Symbol: Pik3r1^tm2Dfr
• Allele Name: targeted mutation 2, David A Fruman
• Allele ID: MGI:4818438
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3r1^tm2Dfr/Pik3r1^tm2Dfr	either: C.129S6-Pik3r1^tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)	MGI:4818440
ht2	Pik3r1^tm2Dfr/Pik3r1^+	involves: 129S6/SvEvTac * BALB/c * C57BL/6	MGI:4818444

Genotype
MGI:4818440

hm1

• Allelic Composition: Pik3r1^tm2Dfr/Pik3r1^tm2Dfr
• Genetic Background: either: C.129S6-Pik3r1^tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:94077 )

• presumed due to liver necrosis

homeostasis/metabolism

hypoglycemia ( J:94077 )

• severe hypoglycemia

chylous ascites ( J:94077 )

immune system

abnormal B cell differentiation ( J:94077 )

• development of B lymphocytes is impaired

hematopoietic system

abnormal erythropoiesis ( J:94077 )

• erythropoiesis is impaired

abnormal B cell differentiation ( J:94077 )

• development of B lymphocytes is impaired

liver/biliary system

hepatic necrosis ( J:94077 )

muscle

increased skeletal muscle fiber size ( J:94077 )

cellular

hepatic necrosis ( J:94077 )

Genotype
MGI:4818444

ht2

• Allelic Composition: Pik3r1^tm2Dfr/Pik3r1⁺
• Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

homeostasis/metabolism

hypoglycemia ( J:94077 )

improved glucose tolerance ( J:94077 )

increased insulin sensitivity ( J:94077 )