Phenotypes associated with this allele

• Allele Symbol: Sh3kbp1^tm1Ivdi
• Allele Name: targeted mutation 1, Ivan Dikic
• Allele ID: MGI:4818424
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh3kbp1^tm1Ivdi/Sh3kbp1^tm1Ivdi	B6.129S-Sh3kbp1^tm1Ivdi	MGI:4818425

Genotype
MGI:4818425

hm1

• Allelic Composition: Sh3kbp1^tm1Ivdi/Sh3kbp1^tm1Ivdi
• Genetic Background: B6.129S-Sh3kbp1^tm1Ivdi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:162088 )

♀

growth/size/body

increased lean body mass ( J:162088 )

♀

behavior/neurological

abnormal behavioral response to xenobiotic ( J:162088 )

♀ • less sensitive to low doses of quinpirole or haloperidol, compared with wild-type littermates

increased exploration in new environment ( J:162088 )

♀ • enhanced exploratory behavior; entering the board more frequently and exploring a larger number of holes on the board, than wild-type animals

abnormal food intake ( J:162088 )

♀ • females show a significant increase in energy uptake compared with their wild-type littermates

increased locomotor activity ( J:162088 )

♀ • enhanced forward locomotor activity, increased turns, velocity and distance traveled

nervous system

abnormal nervous system physiology ( J:162088 )

♀ • the amounts of striatal 3,4-dihydroxyphenylacetic acid and homovanillic acid are higher in the mutant

integument

decreased subcutaneous adipose tissue amount ( J:162088 )

♀

homeostasis/metabolism

increased dopamine level ( J:162088 )

♀ • significantly increased levels of dopamine in the striatum compared with wild-type animals