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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Grb2tm1.1Hua
targeted mutation 1.1, Hua Gu
MGI:4462852
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(DO11.10)10Dlo/0
Tg(Lck-cre)1Jtak/0
involves: 129 * BALB/c * C3H * C57BL/6 MGI:4818271
cn2
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
involves: 129 * C57BL/6 MGI:4818270
cn3
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J MGI:4818273


Genotype
MGI:4818271
cn1
Allelic
Composition
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(DO11.10)10Dlo/0
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (42 available)
Tg(DO11.10)10Dlo mutation (7 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• positive selection of CD4+ cells is severely impaired compared to in DO11.10 TCR control mice

hematopoietic system
• positive selection of CD4+ cells is severely impaired compared to in DO11.10 TCR control mice




Genotype
MGI:4818270
cn2
Allelic
Composition
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (42 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• slightly in the thymus and lymph nodes
• maturation of double positive thymocytes to single positive thymocytes is impaired compared to in wild-type mice
• mice exhibit a marked decrease in CD4+ T cells in the thymus compared with wild-type mice
• peripheral CD4+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
• mice exhibit a moderate decrease in CD8+ T cells in the thymus compared with wild-type mice
• peripheral CD8+ T cells in the spleen and lymph node are decreased compared to in wild-type mice

hematopoietic system
• slightly in the thymus and lymph nodes
• maturation of double positive thymocytes to single positive thymocytes is impaired compared to in wild-type mice
• mice exhibit a marked decrease in CD4+ T cells in the thymus compared with wild-type mice
• peripheral CD4+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
• mice exhibit a moderate decrease in CD8+ T cells in the thymus compared with wild-type mice
• peripheral CD8+ T cells in the spleen and lymph node are decreased compared to in wild-type mice

endocrine/exocrine glands
• slightly in the thymus and lymph nodes




Genotype
MGI:4818273
cn3
Allelic
Composition
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (42 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice
• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice
• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice

hematopoietic system
• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice
• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice
• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory