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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Del(7Slx1b-Sept1)4Aam
deletion, Chr 7, Alea A Mills 4
MGI:4462822
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Del(7Slx1b-Sept1)4Aam/+ involves: 129S7/SvEvBrd MGI:5291507
ht2
Del(7Slx1b-Sept1)4Aam/+ involves: 129S7/SvEvBrd * C57BL/6N MGI:5291505
ot3
Del(7Slx1b-Sept1)4Aam/0 B6129S-Del(7Slx1b-Sept1)4Aam/J MGI:5634817


Genotype
MGI:5291507
ht1
Allelic
Composition
Del(7Slx1b-Sept1)4Aam/+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(7Slx1b-Sept1)4Aam mutation (1 available); any Del(7Slx1b-Sept1)4Aam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die between birth and weaning (J:176335)
• some mice die between birth and weaning (J:176335)




Genotype
MGI:5291505
ht2
Allelic
Composition
Del(7Slx1b-Sept1)4Aam/+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(7Slx1b-Sept1)4Aam mutation (1 available); any Del(7Slx1b-Sept1)4Aam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die between birth and weaning (J:176335)
• some mice die between birth and weaning (J:176335)

behavior/neurological
• mice exhibit higher distance traveled, time spent walking, and time spent lingering compared with control mice (J:176335)
• after habituation, mice exhibit a second burst of activity (walking and rearing) unlike control mice (J:176335)
• mice spend less time resting than control mice (J:176335)
• mice are more active in the dark and light phases compared with control mice (J:176335)
• mice exhibit a higher ratio of light to dark activity compared with control mice (J:176335)
• mice exhibit higher distance traveled, time spent walking, and time spent lingering compared with control mice (J:176335)
• after habituation, mice exhibit a second burst of activity (walking and rearing) unlike control mice (J:176335)
• mice spend less time resting than control mice (J:176335)
• mice are more active in the dark and light phases compared with control mice (J:176335)
• mice exhibit a higher ratio of light to dark activity compared with control mice (J:176335)
• mice exhibit extremely stereotypic ceiling-climbing unlike control mice with some mice becoming trapped on the ceiling for extensive periods (J:176335)
• mice exhibit extremely stereotypic ceiling-climbing unlike control mice with some mice becoming trapped on the ceiling for extensive periods (J:176335)

nervous system
• in the posterior, lateral regions compared with Dp(7Slx1b-Sept1)5Aam mice (J:176335)
• in the posterior, lateral regions compared with Dp(7Slx1b-Sept1)5Aam mice (J:176335)
• in the lateral hypothalamus (J:176335)
• in the lateral hypothalamus (J:176335)

growth/size/body
• prior to weaning but not as adults (J:176335)
• prior to weaning but not as adults (J:176335)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:176335




Genotype
MGI:5634817
ot3
Allelic
Composition
Del(7Slx1b-Sept1)4Aam/0
Genetic
Background
B6129S-Del(7Slx1b-Sept1)4Aam/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(7Slx1b-Sept1)4Aam mutation (1 available); any Del(7Slx1b-Sept1)4Aam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 20% reduction in body weight at P2, P10, and P120 (J:219859)
• 20% reduction in body weight at P2, P10, and P120 (J:219859)

behavior/neurological
• in the elevated plus maze, mice spend less time exploring the open arms, indicating anxiety-like behavior (J:219859)
• in the open field, mice show a decrease in the frequency of entering the center, the middle, and outer parameter of the open field chamber during the first 5 minutes of exploration and a 35% decrease in the total distance traveled (J:219859)
• in the elevated plus maze, mice spend less time exploring the open arms, indicating anxiety-like behavior (J:219859)
• in the open field, mice show a decrease in the frequency of entering the center, the middle, and outer parameter of the open field chamber during the first 5 minutes of exploration and a 35% decrease in the total distance traveled (J:219859)
• in a novel object recognition task, mice are impaired in ability to discriminate between novel and familiar objects, indicating recognition memory deficits (J:219859)
• however, exploration time during habituation phase is not different from wild-type mice (J:219859)
• in a novel object recognition task, mice are impaired in ability to discriminate between novel and familiar objects, indicating recognition memory deficits (J:219859)
• however, exploration time during habituation phase is not different from wild-type mice (J:219859)

nervous system
• increase in the number of proliferating progenitors at early and mid-neurogenesis (E12.5 and E14.5) in both the ventricular zone and subventricular zone (J:219859)
• increase in the number of proliferating progenitors at early and mid-neurogenesis (E12.5 and E14.5) in both the ventricular zone and subventricular zone (J:219859)
• 30% decrease in calretinin-positive interneurons in the upper layers of the cortex (J:219859)
• 30% decrease in calretinin-positive interneurons in the upper layers of the cortex (J:219859)
• modest reduction in brain size during early postnatal development, with a 7% difference by P10, which persists into adulthood (J:219859)
• modest reduction in brain size during early postnatal development, with a 7% difference by P10, which persists into adulthood (J:219859)
• reduced cortical area, specifically anteroposterior length and cortical length at P2 and p10 (J:219859)
• reduced cortical area, specifically anteroposterior length and cortical length at P2 and p10 (J:219859)
• 20-30% decrease in upper layer cortical projection neurons (J:219859)
• 20-30% decrease in upper layer cortical projection neurons (J:219859)
• 11% increase in layer VI corticothalamic Tbr1+ projection neurons (J:219859)
• 11% increase in layer VI corticothalamic Tbr1+ projection neurons (J:219859)
• mice show enhanced neuronal progenitor proliferation and premature cell cycle exit, resulting in premature depletion of progenitor pools, and altering the number and frequency of neurons ultimately populating cortical lamina (J:219859)
• mice show a 20% decrease in the frequency of Brn1+ neurons generated at E14.5 (J:219859)
• progenitors in the telencephalon show premature cell cycle exit during mid-neurogenesis (J:219859)
• mice show enhanced neuronal progenitor proliferation and premature cell cycle exit, resulting in premature depletion of progenitor pools, and altering the number and frequency of neurons ultimately populating cortical lamina (J:219859)
• mice show a 20% decrease in the frequency of Brn1+ neurons generated at E14.5 (J:219859)
• progenitors in the telencephalon show premature cell cycle exit during mid-neurogenesis (J:219859)
• mice exhibit a decrease in basal progenitor number and generation, resulting in premature progenitor pool depletion (J:219859)
• generation and number of Tbr2+ intermediate progenitor cells are decreased (J:219859)
• the number of Pax6+Tbr2+ progenitors is reduced by 40% and the number of transitioning Pax6+Tbr2+ progenitors is reduced (J:219859)
• the number of Tbr2+ intermediate progenitor cells in the cortical proliferation zones is reduced by nearly 20% (J:219859)
• mice exhibit a decrease in basal progenitor number and generation, resulting in premature progenitor pool depletion (J:219859)
• generation and number of Tbr2+ intermediate progenitor cells are decreased (J:219859)
• the number of Pax6+Tbr2+ progenitors is reduced by 40% and the number of transitioning Pax6+Tbr2+ progenitors is reduced (J:219859)
• the number of Tbr2+ intermediate progenitor cells in the cortical proliferation zones is reduced by nearly 20% (J:219859)
• reduction in the number of Pax6+ radial glia (J:219859)
• reduction in the number of Pax6+ radial glia (J:219859)

cellular
• mice exhibit a decrease in basal progenitor number and generation, resulting in premature progenitor pool depletion (J:219859)
• generation and number of Tbr2+ intermediate progenitor cells are decreased (J:219859)
• the number of Pax6+Tbr2+ progenitors is reduced by 40% and the number of transitioning Pax6+Tbr2+ progenitors is reduced (J:219859)
• the number of Tbr2+ intermediate progenitor cells in the cortical proliferation zones is reduced by nearly 20% (J:219859)
• mice exhibit a decrease in basal progenitor number and generation, resulting in premature progenitor pool depletion (J:219859)
• generation and number of Tbr2+ intermediate progenitor cells are decreased (J:219859)
• the number of Pax6+Tbr2+ progenitors is reduced by 40% and the number of transitioning Pax6+Tbr2+ progenitors is reduced (J:219859)
• the number of Tbr2+ intermediate progenitor cells in the cortical proliferation zones is reduced by nearly 20% (J:219859)
• reduction in the number of Pax6+ radial glia (J:219859)
• reduction in the number of Pax6+ radial glia (J:219859)
• increase in the number of proliferating progenitors at early and mid-neurogenesis (E12.5 and E14.5) in both the ventricular zone and subventricular zone (J:219859)
• increase in the number of proliferating progenitors at early and mid-neurogenesis (E12.5 and E14.5) in both the ventricular zone and subventricular zone (J:219859)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:219859





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory