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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgfr2m1Sgg
mutation 1, S G Gong
MGI:4461798
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fgfr2m1Sgg/Fgfr2m1Sgg involves: C3H/HeJ * C57BL/6J MGI:4461806
ht2
Fgfr2m1Sgg/Fgfr2+ involves: C3H/HeJ * C57BL/6J MGI:4461807


Genotype
MGI:4461806
hm1
Allelic
Composition
Fgfr2m1Sgg/Fgfr2m1Sgg
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2m1Sgg mutation (0 available); any Fgfr2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

skeleton
• cranial bones are smaller that in wild-type mice
• sutural spaces are wider than in wild-type mice
• mice exhibit zygomatic arch fused together at the anterior joint unlike in wild-type mice
• teeth fail to develop beyond the bud stage unlike in wild-type mice
• secondary palate shelves remain vertical and short unlike in wild-type mice
• sternal thickening, cartilage ossification and misalignment, and abnormal bifurcation of the bone and cartilage structures that cap the ends of the sternum
• mice exhibit some incompletely formed and fused vertebrae unlike wild-type mice
• fewer Runx2+ cells are found surrounding the edge of the coronal sutures compared to in wild-type mice
• the cartilage beneath the cranial vault is thickened compared to in wild-type mice
• at P0, the nasal capsule is shorter antero-posteriorly with a thickened nasal septum compared to in wild-type mice
• chondrocytes in the nasal septum are small and disorganized compared to in wild-type mice
• cranial vault bones fail to ossify unlike in wild-type mice

respiratory system
• at P0, the nasal capsule is shorter antero-posteriorly with a thickened nasal septum compared to in wild-type mice
• the nasal septum is thickened compared to in wild-type mice
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice
• mice lack lobular lung structures unlike wild-type mice

endocrine/exocrine glands

growth/size/body
• teeth fail to develop beyond the bud stage unlike in wild-type mice
• secondary palate shelves remain vertical and short unlike in wild-type mice
• at P0, the nasal capsule is shorter antero-posteriorly with a thickened nasal septum compared to in wild-type mice
• primary and secondary formation is retarded compared to in wild-type mice
• tongue shape is abnormal and trapezoid unlike in wild-type mice
• the nasal septum is thickened compared to in wild-type mice
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice

vision/eye

hearing/vestibular/ear
• the ear capsule is reduced in size compared to in wild-type mice

digestive/alimentary system
• mice exhibit shorter gastrointestinal tract compared with wild-type mice
• the abdominal cavity is relatively empty compared to in wild-type mice
• secondary palate shelves remain vertical and short unlike in wild-type mice
• primary and secondary formation is retarded compared to in wild-type mice
• tongue shape is abnormal and trapezoid unlike in wild-type mice

limbs/digits/tail
• limb growth is arrested distal to the scapula unlike in wild-type mice

nervous system

renal/urinary system

craniofacial
• cranial bones are smaller that in wild-type mice
• sutural spaces are wider than in wild-type mice
• mice exhibit zygomatic arch fused together at the anterior joint unlike in wild-type mice
• teeth fail to develop beyond the bud stage unlike in wild-type mice
• secondary palate shelves remain vertical and short unlike in wild-type mice
• at P0, the nasal capsule is shorter antero-posteriorly with a thickened nasal septum compared to in wild-type mice
• primary and secondary formation is retarded compared to in wild-type mice
• tongue shape is abnormal and trapezoid unlike in wild-type mice
• the nasal septum is thickened compared to in wild-type mice
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice

embryo

Mouse Models of Human Disease
OMIM ID Ref(s)
Crouzon Syndrome 123500 J:160674




Genotype
MGI:4461807
ht2
Allelic
Composition
Fgfr2m1Sgg/Fgfr2+
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2m1Sgg mutation (0 available); any Fgfr2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• at 3 weeks of age, mice exhibit short snout, retruded mid-face, and variable septal deviation unlike wild-type mice
• sutural spaces are wider than in wild-type mice
• premature fusion in some mice
• mice exhibit decreased antero-posterior skull length compared with wild-type mice
• mice exhibit a delay in horizontal secondary palate formation in the posterior edge of the maxillary bone and hard tissue clefts on the secondary palate compared with wild-type mice
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice

growth/size/body
N
• 3 weeks postnatal, mice exhibit normal body size and weight
• mice exhibit a delay in horizontal secondary palate formation in the posterior edge of the maxillary bone and hard tissue clefts on the secondary palate compared with wild-type mice
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice

digestive/alimentary system
• mice exhibit a delay in horizontal secondary palate formation in the posterior edge of the maxillary bone and hard tissue clefts on the secondary palate compared with wild-type mice

embryo

hearing/vestibular/ear
• the ear capsule is reduced in size compared to in wild-type mice

respiratory system
• nasal septum shows a lack of ordered columnar organization of chondrocytes compared to in wild-type mice

skeleton
• sutural spaces are wider than in wild-type mice
• premature fusion in some mice
• mice exhibit decreased antero-posterior skull length compared with wild-type mice
• fewer Runx2+ cells are found surrounding the edge of the coronal sutures compared to in wild-type mice
• pericellular spaces in the nasal septum chondrocytes are bigger than in wild-type mice
• of coronal closure in some mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Crouzon Syndrome 123500 J:160674





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory