Mouse Genome Informatics
hm1
    Lrrk2tm2.1Shn/Lrrk2tm2.1Shn
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
renal/urinary system
• at 20 months, mice exhibit increased apoptosis in the medulla, renal tubules, and glomeruli compared with wild-type mice
• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys
• at 20 months
• at 20 months, kidneys appear rough and granular, are smaller, weigh less, and are darker than in wild-type mice
• however, kidneys are normal at 10 weeks
• at 20 months, kidneys exhibit accumulation and aggregation of alpha-synuclein and ubiquitinated proteins compared with wild-type
• at 20 months, lipofuscin granules accumulate in the kidneys unlike in wild-type mice
• at 20 months
• at 20 months
• in aged mice
• at 20 months

cellular
• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys
• at 20 months, mice exhibit increased apoptosis in the medulla, renal tubules, and glomeruli compared with wild-type mice
• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys

pigmentation
• at 20 months, lipofuscin granules accumulate in the kidneys unlike in wild-type mice

nervous system
N
• mice exhibit normal dopaminergic neurons and dopamine turnover (J:160542)

immune system
• at 20 months