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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lrrk2tm2.1Shn
targeted mutation 2.1, Jie Shen
MGI:4460960
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lrrk2tm2.1Shn/Lrrk2tm2.1Shn involves: 129 * C57BL/6 MGI:4460974


Genotype
MGI:4460974
hm1
Allelic
Composition
Lrrk2tm2.1Shn/Lrrk2tm2.1Shn
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrk2tm2.1Shn mutation (1 available); any Lrrk2 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• at 20 months, mice exhibit increased apoptosis in the medulla, renal tubules, and glomeruli compared with wild-type mice
• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys
• at 20 months
• at 20 months, kidneys appear rough and granular, are smaller, weigh less, and are darker than in wild-type mice
• however, kidneys are normal at 10 weeks
• at 20 months, kidneys exhibit accumulation and aggregation of alpha-synuclein and ubiquitinated proteins compared with wild-type
• at 20 months, lipofuscin granules accumulate in the kidneys unlike in wild-type mice
• at 20 months
• at 20 months
• in aged mice
• at 20 months

cellular
• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys
• at 20 months, mice exhibit increased apoptosis in the medulla, renal tubules, and glomeruli compared with wild-type mice
• at 20 months, kidneys exhibit impaired autophagy-lysosomal pathways compared with wild-type kidneys

pigmentation
• at 20 months, lipofuscin granules accumulate in the kidneys unlike in wild-type mice

nervous system
N
• mice exhibit normal dopaminergic neurons and dopamine turnover

immune system
• at 20 months





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory