hm1

Spns2^{tm1a(KOMP)Wtsi}/Spns2^{tm1a(KOMP)Wtsi}
C57BL/6-Spns2^{tm1a(KOMP)Wtsi}

cell line(s): EPD0090_5_B04

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

immune system

immune system phenotype ( J:188933 )

N	• mice exhibit normal early B cell development (J:188933) • macrophage exhibit normal responses to inflammatory stimuli (J:188933)

increased CD4-positive T cell number ( J:188933 )

• moderate in the thymus

increased CD8-positive T cell number ( J:188933 )

• moderate in the thymus

decreased leukocyte cell number ( J:188933 )

decreased B cell number ( J:188933 )

• circulating

decreased B-1 B cell number ( J:188933 )

• in the peritoneal cavity

decreased follicular B cell number ( J:188933 )

decreased CD4-positive T cell number ( J:188933 )

• 4-fold in the spleen

decreased CD8-positive T cell number ( J:188933 )

• 4-fold in the spleen

abnormal humoral immune response ( J:188933 )

decreased IgG level ( J:188933 )

• in response to immune challenge

decreased IgG1 level ( J:188933 )

• in response to immune challenge

vision/eye

abnormal eye pigmentation ( J:188933 )

eye opacity ( J:188933 )

pigmentation

abnormal eye pigmentation ( J:188933 )

hematopoietic system

increased CD4-positive T cell number ( J:188933 )

• moderate in the thymus

increased CD8-positive T cell number ( J:188933 )

• moderate in the thymus

decreased leukocyte cell number ( J:188933 )

decreased B cell number ( J:188933 )

• circulating

decreased B-1 B cell number ( J:188933 )

• in the peritoneal cavity

decreased follicular B cell number ( J:188933 )

decreased CD4-positive T cell number ( J:188933 )

• 4-fold in the spleen

decreased CD8-positive T cell number ( J:188933 )

• 4-fold in the spleen

behavior/neurological

absent pinna reflex ( J:175295 )

WTSI (J:175295)

cardiovascular system

corneal vascularization ( J:175295 )

WTSI (J:175295)

hematopoietic system

increased NK cell number ( J:175295 )

WTSI (J:175295)

increased NK T cell number ( J:175295 )

WTSI (J:175295)

decreased leukocyte cell number ( J:175295 )

WTSI (J:175295)

decreased B cell number ( J:175295 )

WTSI (J:175295)

decreased mature B cell number ( J:175295 )

WTSI (J:175295)

decreased T cell number ( J:175295 )

WTSI (J:175295)

decreased CD4-positive T cell number ( J:175295 )

WTSI (J:175295)

decreased CD8-positive T cell number ( J:175295 )

WTSI (J:175295)

increased granulocyte number ( J:175295 )

WTSI (J:175295)

increased monocyte cell number ( J:175295 )

WTSI (J:175295)

homeostasis/metabolism

increased circulating bilirubin level ( J:175295 )

WTSI (J:175295)

decreased circulating glucose level ( J:175295 )

WTSI (J:175295)

immune system

increased NK cell number ( J:175295 )

WTSI (J:175295)

increased NK T cell number ( J:175295 )

WTSI (J:175295)

decreased leukocyte cell number ( J:175295 )

WTSI (J:175295)

decreased B cell number ( J:175295 )

WTSI (J:175295)

decreased mature B cell number ( J:175295 )

WTSI (J:175295)

decreased T cell number ( J:175295 )

WTSI (J:175295)

decreased CD4-positive T cell number ( J:175295 )

WTSI (J:175295)

decreased CD8-positive T cell number ( J:175295 )

WTSI (J:175295)

increased granulocyte number ( J:175295 )

WTSI (J:175295)

increased monocyte cell number ( J:175295 )

WTSI (J:175295)

increased susceptibility to bacterial infection ( J:175295 )

WTSI (J:175295)

pigmentation

abnormal eye pigmentation ( J:175295 )

WTSI (J:175295)

vision/eye

abnormal eye pigmentation ( J:175295 )

WTSI (J:175295)

abnormal pupil morphology ( J:175295 )

WTSI (J:175295)

abnormal cornea morphology ( J:175295 )

WTSI (J:175295)

corneal vascularization ( J:175295 )

WTSI (J:175295)

corneal opacity ( J:175295 )

WTSI (J:175295)

narrow eye opening ( J:175295 )

WTSI (J:175295)

eyelids fail to open ( J:175295 )

WTSI (J:175295)

eye opacity ( J:175295 )

WTSI (J:175295)

hm3

Spns2^{tm1a(KOMP)Wtsi}/Spns2^{tm1a(KOMP)Wtsi}
Not Specified

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

behavior/neurological

abnormal startle reflex ( J:165965 )

EuPh (J:165965)

cardiovascular system

corneal vascularization ( J:165965 )

EuPh (J:165965)

hematopoietic system

decreased leukocyte cell number ( J:165965 )

EuPh (J:165965)

immune system

decreased leukocyte cell number ( J:165965 )

EuPh (J:165965)

pigmentation

abnormal eye pigmentation ( J:165965 )

EuPh (J:165965)

skeleton

abnormal rib morphology ( J:165965 )

EuPh (J:165965)

decreased lumbar vertebrae number ( J:165965 )

EuPh (J:165965)

increased sacral vertebrae number ( J:165965 )

EuPh (J:165965)

increased bone mineral density ( J:165965 )

EuPh (J:165965)

vision/eye

abnormal eye morphology ( J:165965 )

EuPh (J:165965)

abnormal eye pigmentation ( J:165965 )

EuPh (J:165965)

abnormal iris morphology ( J:165965 )

EuPh (J:165965)

abnormal pupil morphology ( J:165965 )

EuPh (J:165965)

abnormal cornea morphology ( J:165965 )

EuPh (J:165965)

corneal vascularization ( J:165965 )

EuPh (J:165965)

corneal opacity ( J:165965 )

EuPh (J:165965)

abnormal eye size ( J:165965 )

EuPh (J:165965)

abnormal eyelid aperture ( J:165965 )

EuPh (J:165965)

excessive tearing ( J:165965 )

EuPh (J:165965)

ot4

Spns2^{tm1a(KOMP)Wtsi}/?
Not Specified

cell line(s): EPD0090_5_B04

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

hearing/vestibular/ear

abnormal auditory brainstem response ( J:175295 )

WTSI (J:175295)

skeleton

increased bone mineral content ( J:175295 )

WTSI (J:175295)

increased bone strength ( J:175295 )

WTSI (J:175295)

vision/eye

abnormal iridocorneal angle ( J:175295 )

WTSI (J:175295)

abnormal ciliary body morphology ( J:175295 )

WTSI (J:175295)

abnormal iris morphology ( J:175295 )

WTSI (J:175295)

abnormal corneal stroma morphology ( J:175295 )

WTSI (J:175295)

corneal opacity ( J:175295 )

WTSI (J:175295)

cataracts ( J:175295 )

WTSI (J:175295)

small lens ( J:175295 )

WTSI (J:175295)

microphthalmia ( J:175295 )

WTSI (J:175295)

abnormal retina morphology ( J:175295 )

WTSI (J:175295)