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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spns2tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4460276
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi C57BL/6-Spns2tm1a(KOMP)Wtsi MGI:5442811
hm2
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi Not Specified MGI:5450240
hm3
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi Not Specified MGI:5450669
ot4
Spns2tm1a(KOMP)Wtsi/? Not Specified MGI:5450241


Genotype
MGI:5442811
hm1
Allelic
Composition
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic
Background
C57BL/6-Spns2tm1a(KOMP)Wtsi
Cell Lines EPD0090_5_B04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spns2tm1a(KOMP)Wtsi mutation (2 available); any Spns2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal early B cell development (J:188933)
• macrophage exhibit normal responses to inflammatory stimuli (J:188933)
• mice exhibit normal early B cell development (J:188933)
• macrophage exhibit normal responses to inflammatory stimuli (J:188933)
• moderate in the thymus (J:188933)
• moderate in the thymus (J:188933)
• moderate in the thymus (J:188933)
• moderate in the thymus (J:188933)
• circulating (J:188933)
• circulating (J:188933)
• in the peritoneal cavity (J:188933)
• in the peritoneal cavity (J:188933)
• 4-fold in the spleen (J:188933)
• 4-fold in the spleen (J:188933)
• 4-fold in the spleen (J:188933)
• 4-fold in the spleen (J:188933)
• in response to immune challenge (J:188933)
• in response to immune challenge (J:188933)
• in response to immune challenge (J:188933)
• in response to immune challenge (J:188933)

vision/eye

pigmentation

hematopoietic system
• moderate in the thymus (J:188933)
• moderate in the thymus (J:188933)
• moderate in the thymus (J:188933)
• moderate in the thymus (J:188933)
• circulating (J:188933)
• circulating (J:188933)
• in the peritoneal cavity (J:188933)
• in the peritoneal cavity (J:188933)
• 4-fold in the spleen (J:188933)
• 4-fold in the spleen (J:188933)
• 4-fold in the spleen (J:188933)
• 4-fold in the spleen (J:188933)
• in response to immune challenge (J:188933)
• in response to immune challenge (J:188933)
• in response to immune challenge (J:188933)
• in response to immune challenge (J:188933)




Genotype
MGI:5450240
hm2
Allelic
Composition
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic
Background
Not Specified
Cell Lines EPD0090_5_B04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spns2tm1a(KOMP)Wtsi mutation (2 available); any Spns2 mutation (4 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
WTSI (J:175295)
WTSI (J:175295)

cardiovascular system
WTSI (J:175295)
WTSI (J:175295)

hematopoietic system
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)

homeostasis/metabolism
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)

immune system
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)

pigmentation
WTSI (J:175295)
WTSI (J:175295)

vision/eye
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)




Genotype
MGI:5450669
hm3
Allelic
Composition
Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spns2tm1a(KOMP)Wtsi mutation (2 available); any Spns2 mutation (4 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
EuPh (J:165965)
EuPh (J:165965)

cardiovascular system
EuPh (J:165965)
EuPh (J:165965)

hematopoietic system
EuPh (J:165965)
EuPh (J:165965)

immune system
EuPh (J:165965)
EuPh (J:165965)

pigmentation
EuPh (J:165965)
EuPh (J:165965)

skeleton
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)

vision/eye
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)




Genotype
MGI:5450241
ot4
Allelic
Composition
Spns2tm1a(KOMP)Wtsi/?
Genetic
Background
Not Specified
Cell Lines EPD0090_5_B04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spns2tm1a(KOMP)Wtsi mutation (2 available); any Spns2 mutation (4 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
WTSI (J:175295)
WTSI (J:175295)

skeleton
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)

vision/eye
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)
WTSI (J:175295)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory