Analysis Tools
normal phenotype
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• mice develop normally, reach adulthood, are fertile, and exhibit normal glucose levels in the urine
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Allele Symbol Allele Name Allele ID |
Neurog3tm3.1Ggr targeted mutation 3.1, Gerard Gradwohl MGI:4460088 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop normally, reach adulthood, are fertile, and exhibit normal glucose levels in the urine
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Loss of enteroendocrine cells in Neurog3tm1Fgu/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 and Neurog3tm3.1Ggr/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 mice
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• 50% of mice die within the first 8 days of life
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• goblet cells in the large intestine are larger than in wild-type mice and mostly devoid of mucus
• however, goblet cell numbers are normal in the small intestine
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• at E19.5, crypt cell proliferation is increased compared to in wild-type mice
• in adult mice, crypt cell proliferation is increased with an up to 1.6-fold increase in cell turnover compared to in wild-type mice
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• as early as embryogenesis, mice lack enteroendocrine progenitors along the proximal-distal axis of the intestine unlike in wild-type mice
• however, intestinal epithelial cell proliferation is normal
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• as early as embryogenesis, mice lack enteroendocrine progenitors along the proximal-distal axis of the intestine unlike in wild-type mice
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• small intestine crypts are disorganized, larger, and more abundant than in wild-type mice
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• the large intestine exhibits a reduction in the length of glands of up to 1.5 times compared with wild-type mice
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• villi are blunted or club shaped with frequent dilation and strong detachment of the epithelium from the basement membrane unlike in wild-type mice
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• microvilli on absorptive cells are sparser, 60% shorter, but twice as large as on wild-type cells
• the brush border of absorptive cells in the small intestine is reduced 44% compared to in wild-type mice
• however, expression of brush border enzymes and glucose transporters is normal
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• 60% shorter than in wild-type mice
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• mice produce more feces compared with wild-type mice
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• surviving mice exhibit soft stool that does not cease with age unlike in wild-type mice
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• impaired
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• mice excrete yellowish stool unlike wild-type mice
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• intestinal transit time is increased 2.3-fold compared to in wild-type mice
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• impaired
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• mice excrete yellowish stool unlike wild-type mice
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• slightly
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• slightly
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• in an intraperitoneal glucose tolerance test, mice exhibit lower serum glucose levels than in similarly treated wild-type mice
• fasting mice exhibit decreased blood glucose compared with similarly treated wild-type mice
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• in an oral glucose tolerance test, mice exhibit improved glucose clearance compared with similarly treated wild-type mice
• in an intraperitoneal glucose tolerance test, mice exhibit lower serum glucose levels than in similarly treated wild-type mice
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• slightly at 14 and 17 weeks
• insulin-mediated hypoglycemic response is blunted compared to in wild-type mice
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• mice exhibit reduced abdominal fat compared with wild-type mice
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• small intestine crypts are disorganized, larger, and more abundant than in wild-type mice
|
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• mice exhibit more medium and large islets with centrally located alpha cells than in wild-type mice
|
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• mice exhibit a shift from large to single islets compared with wild-type mice
|
|
• goblet cells in the large intestine are larger than in wild-type mice and mostly devoid of mucus
• however, goblet cell numbers are normal in the small intestine
|
|
• at E19.5, crypt cell proliferation is increased compared to in wild-type mice
• in adult mice, crypt cell proliferation is increased with an up to 1.6-fold increase in cell turnover compared to in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Loss of enteroendocrine cells in Neurog3tm1Fgu/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 and Neurog3tm3.1Ggr/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 mice
|
• 50% of mice die within the first 8 days of life
|
|
• impaired
|
|
• mice excrete yellowish stool unlike wild-type mice
|
|
• slightly
|
|
• slightly
|
|
• in an intraperitoneal glucose tolerance test, mice exhibit lower serum glucose levels than in similarly treated wild-type mice
• fasting mice exhibit decreased blood glucose compared with similarly treated wild-type mice
|
|
• in an oral glucose tolerance test, mice exhibit improved glucose clearance compared with similarly treated wild-type mice
• in an intraperitoneal glucose tolerance test, mice exhibit lower serum glucose levels than in similarly treated wild-type mice
|
|
• slightly at 14 and 17 weeks
• insulin-mediated hypoglycemic response is blunted compared to in wild-type mice
|
|
• goblet cells in the large intestine are larger than in wild-type mice and mostly devoid of mucus
• however, goblet cell numbers are normal in the small intestine
|
|
• at E19.5, crypt cell proliferation is increased compared to in wild-type mice
• in adult mice, crypt cell proliferation is increased with an up to 1.6-fold increase in cell turnover compared to in wild-type mice
|
|
• as early as embryogenesis, mice lack enteroendocrine progenitors along the proximal-distal axis of the intestine unlike in wild-type mice
• however, intestinal epithelial cell proliferation is normal
|
|
• as early as embryogenesis, mice lack enteroendocrine progenitors along the proximal-distal axis of the intestine unlike in wild-type mice
|
|
• small intestine crypts are disorganized, larger, and more abundant than in wild-type mice
|
|
• the large intestine exhibits a reduction in the length of glands of up to 1.5 times compared with wild-type mice
|
|
• villi are blunted or club shaped with frequent dilation and strong detachment of the epithelium from the basement membrane unlike in wild-type mice
|
|
• microvilli on absorptive cells are sparser, 60% shorter, but twice as large as on wild-type cells
• the brush border of absorptive cells in the small intestine is reduced 44% compared to in wild-type mice
• however, expression of brush border enzymes and glucose transporters is normal
|
|
• 60% shorter than in wild-type mice
|
|
• mice produce more feces compared with wild-type mice
|
|
• surviving mice exhibit soft stool that does not cease with age unlike in wild-type mice
|
|
• impaired
|
|
• mice excrete yellowish stool unlike wild-type mice
|
|
• intestinal transit time is increased 2.3-fold compared to in wild-type mice
|
|
• mice exhibit reduced abdominal fat compared with wild-type mice
|
|
• small intestine crypts are disorganized, larger, and more abundant than in wild-type mice
|
|
• mice exhibit more medium and large islets with centrally located alpha cells than in wild-type mice
|
|
• mice exhibit a shift from large to single islets compared with wild-type mice
|
|
• goblet cells in the large intestine are larger than in wild-type mice and mostly devoid of mucus
• however, goblet cell numbers are normal in the small intestine
|
|
• at E19.5, crypt cell proliferation is increased compared to in wild-type mice
• in adult mice, crypt cell proliferation is increased with an up to 1.6-fold increase in cell turnover compared to in wild-type mice
|
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal sensitivity to DSS-induced colitis
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• EECs absent
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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