Phenotypes associated with this allele

• Allele Symbol: Clec4n^tm1Yiw
• Allele Name: targeted mutation 1, Yoichiro Iwakura
• Allele ID: MGI:4459637
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4n^tm1Yiw/Clec4n^tm1Yiw	B6.129P2-Clec4n^tm1Yiw	MGI:4459638
hm2	Clec4n^tm1Yiw/Clec4n^tm1Yiw	involves: 129P2/OlaHsd	MGI:5582832

Genotype
MGI:4459638

hm1

• Allelic Composition: Clec4n^tm1Yiw/Clec4n^tm1Yiw
• Genetic Background: B6.129P2-Clec4n^tm1Yiw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to infection induced morbidity/mortality ( J:160680 )

• have a significantly lower survival than wild-type mice when they were infected with a semilethal dose intravenously of by BMDCs ATCC18804

• normal response to semilethal dose of Cryptococcus neoformans

immune system

abnormal CD4-positive T cell differentiation ( J:160680 )

• failure of BMDCs to produce Th17 or Th1 polarizing media in response to yeast or hyphae forms of C.albicans

decreased interferon-gamma secretion ( J:160680 )

• by BMDC in response to yeast form of C. albicans stimulation

decreased interleukin-10 secretion ( J:160680 )

• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

decreased interleukin-12b secretion ( J:160680 )

• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

decreased interleukin-17 secretion ( J:160680 )

• decreased IL17A secretion by BMDC in response to yeast or hyphae forms of C. albicans stimulation

decreased interleukin-23 secretion ( J:160680 )

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

decreased interleukin-6 secretion ( J:160680 )

• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

decreased tumor necrosis factor secretion ( J:160680 )

• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

increased susceptibility to infection induced morbidity/mortality ( J:160680 )

• have a significantly lower survival than wild-type mice when they were infected with a semilethal dose intravenously of by BMDCs ATCC18804

• normal response to semilethal dose of Cryptococcus neoformans

renal/urinary system

abnormal kidney pelvis morphology ( J:160680 )

• neutrophil infiltration is accelerated in nodular lesions

hydronephrosis ( J:160680 )

• in response to a semilethal dose intravenously of by BMDCs ATCC18804

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:160680 )

• failure of BMDCs to produce Th17 or Th1 polarizing media in response to yeast or hyphae forms of C.albicans

Genotype
MGI:5582832

hm2

• Allelic Composition: Clec4n^tm1Yiw/Clec4n^tm1Yiw
• Genetic Background: involves: 129P2/OlaHsd

immune system

increased susceptibility to fungal infection ( J:209284 )

• mice infected with Candida glabrata exhibit higher loads in the kidney compared to in wild-type mice