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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pknox1tm1Ngc
targeted mutation 1, Neal G Copeland
MGI:4459452
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pknox1tm1Ngc/Pknox1tm1Ngc Not Specified MGI:4460923
cx2
 		Pknox1tm1Ngc/Pknox1+
Tg(IghMyc)22Bri/0 		involves: C57BL * SJL MGI:5469883


Genotype
MGI:4460923
hm1
Allelic
Composition		 Pknox1tm1Ngc/Pknox1tm1Ngc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1tm1Ngc mutation (0 available); any Pknox1 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5469883
cx2
Allelic
Composition		 Pknox1tm1Ngc/Pknox1+
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1tm1Ngc mutation (0 available); any Pknox1 mutation (90 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Pro-B tumor in Pknox1tm1Ngc/Pknox1+ Tg(IghMyc)22Bri/0 mice

mortality/aging
premature death ( J:192251 )
• median survival time is 23 weeks compared with 58 weeks for Tg(IghMyc)22Bri mice

immune system
decreased B cell apoptosis ( J:192251 )
• in the spleen

neoplasm
increased B cell derived lymphoma incidence ( J:192251 )
• accelerated and enhanced immature B cell lymphomas compared with Tg(IghMyc)22Bri mice

cellular
decreased B cell apoptosis ( J:192251 )
• in the spleen

hematopoietic system
decreased B cell apoptosis ( J:192251 )
• in the spleen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory