Mouse Genome Informatics
tg1
    Tg(Mbp-Pad2)28Fgm/Tg(Mbp-Pad2)28Fgm
involves: CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• no signs of immune cell infiltrates are detected (J:142650)
• develop convulsions by 1.5 months of age
• thickened astrocytic processes are seen in the optic nerve
• optic nerves display areas of myelinolysis and thinly myelinated axons
• gene dosage correlated decrease in myelinated fiber density and myelin thickness
• however, no defects in myelin are detected in the peripheral nervous system (assayed in the sciatic nerve)
• show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age
• signs increase in severity with age more rapidly than in hemizygous mice
• decrease in myelination and irregular axonal staining in the brain
• myelin degradation, nude axons and thinly myelinated axons in the presence of myelinolysis are seen in the optic nerve

behavior/neurological
• develop tremors by 1.5 months of age
• display proprioceptive positioning defects at 4 months of age
• effects are more severe than in hemizygous mice
• becomes impaired by 1.5 months of age
• at 4 months of age
• effects are more severe than in hemizygous mice
• at 4 months of age
• effects are more severe than in hemizygous mice
• hind end weakness is seen at 4 months of age
• develop tail droop by 1.5 months of age
• develop a shaky gait by 1.5 months of age
• at 4 months of age the gait abnormality is more severe in the hind limbs
• develops by 1.5 months of age
• develop convulsions by 1.5 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:142650


Mouse Genome Informatics
tg2
    Tg(Mbp-Pad2)28Fgm/0
involves: CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• develop convulsions by 1.5 months of age
• in the cerebellum and C1-C5 regions of the spinal cord at 6 months of age
• optic nerves display areas of myelinolysis and thinly myelinated axons
• gene dosage correlated decrease in myelinated fiber density and myelin thickness
• show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age
• signs increase in severity with age but not as rapidly as in homozygous mice

behavior/neurological
• develop tremors by 1.5 months of age
• display proprioceptive positioning defects at 4 months of age
• becomes impaired by 1.5 months of age
• at 4 months of age
• at 4 months of age
• develop tail droop by 1.5 months of age
• develop a shaky gait by 1.5 months of age
• develops by 1.5 months of age
• develop convulsions by 1.5 months of age

homeostasis/metabolism
• increase in the levels in the brain by 4 months of age

immune system
• increase in the levels in the brain by 4 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:142650