• no signs of immune cell infiltrates are detected (J:142650)

• develop convulsions by 1.5 months of age

• thickened astrocytic processes are seen in the optic nerve

• optic nerves display areas of myelinolysis and thinly myelinated axons

• gene dosage correlated decrease in myelinated fiber density and myelin thickness

• however, no defects in myelin are detected in the peripheral nervous system (assayed in the sciatic nerve)

• show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age

• signs increase in severity with age more rapidly than in hemizygous mice

• decrease in myelination and irregular axonal staining in the brain

• myelin degradation, nude axons and thinly myelinated axons in the presence of myelinolysis are seen in the optic nerve

• develop tremors by 1.5 months of age

• display proprioceptive positioning defects at 4 months of age

• effects are more severe than in hemizygous mice

• becomes impaired by 1.5 months of age

• at 4 months of age

• effects are more severe than in hemizygous mice

• at 4 months of age

• effects are more severe than in hemizygous mice

• hind end weakness is seen at 4 months of age

• develop tail droop by 1.5 months of age

• develop a shaky gait by 1.5 months of age

• at 4 months of age the gait abnormality is more severe in the hind limbs

• develops by 1.5 months of age

• develop convulsions by 1.5 months of age

• develop convulsions by 1.5 months of age

• in the cerebellum and C1-C5 regions of the spinal cord at 6 months of age

• optic nerves display areas of myelinolysis and thinly myelinated axons

• gene dosage correlated decrease in myelinated fiber density and myelin thickness

• show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age

• signs increase in severity with age but not as rapidly as in homozygous mice

• develop tremors by 1.5 months of age

• display proprioceptive positioning defects at 4 months of age

• becomes impaired by 1.5 months of age

• at 4 months of age

• at 4 months of age

• develop tail droop by 1.5 months of age

• develop a shaky gait by 1.5 months of age

• develops by 1.5 months of age

• develop convulsions by 1.5 months of age

• increase in the levels in the brain by 4 months of age

• increase in the levels in the brain by 4 months of age