Phenotypes associated with this allele

• Allele Symbol: Tfr2^tm1.1Anro
• Allele Name: targeted mutation 1.1, Antonella Roetto
• Allele ID: MGI:4458417
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfr2^tm1.1Anro/Tfr2^tm1.1Anro	129.Cg-Tfr2^tm1.1Anro	MGI:4458421
cn2	Tg(Alb1-cre)7Gsc/0 Tfr2^tm1.1Anro/Tfr2^tm1.1Anro	involves: 129/Sv * C57BL/6 * FVB/N	MGI:4458422

Genotype
MGI:4458421

hm1

• Allelic Composition: Tfr2^tm1.1Anro/Tfr2^tm1.1Anro
• Genetic Background: 129.Cg-Tfr2^tm1.1Anro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

macrocytic anemia ( J:160785 )

• at P14 but reach wild-type hematologic parameters by 10 weeks

increased cellular hemoglobin content ( J:160785 )

• in adult mice

increased hemoglobin content ( J:160785 )

• in adult mice

increased spleen iron level ( J:160785 )

• at 10 weeks and 52 weeks

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:160785 )

N • at 10 weeks, mice exhibit normal transferrin saturation

increased spleen iron level ( J:160785 )

• at 10 weeks and 52 weeks

increased liver iron level ( J:160785 )

• at 22 and 52 weeks but not in young mice

growth/size/body

decreased body weight ( J:160785 )

• at P14 but reach wild-type weight by 10 weeks

immune system

increased spleen iron level ( J:160785 )

• at 10 weeks and 52 weeks

liver/biliary system

increased liver iron level ( J:160785 )

• at 22 and 52 weeks but not in young mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 3		DOID:0111030	OMIM:604250	J:160785

Genotype
MGI:4458422

cn2

• Allelic Composition: Tg(Alb1-cre)7Gsc/0; Tfr2^tm1.1Anro/Tfr2^tm1.1Anro
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

homeostasis/metabolism

increased circulating iron level ( J:160785 )

• at 10 weeks

increased liver iron level ( J:160785 )

• at P14 and further at 22 and 52 weeks

liver/biliary system

increased liver iron level ( J:160785 )

• at P14 and further at 22 and 52 weeks

hematopoietic system

hematopoietic system phenotype ( J:160785 )

N • adult mice exhibit normal hematologic values