Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm2tm1.1Pdc mutation
(1 available);
any
Dnm2 mutation
(99 available)
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normal phenotype
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• mice are healthy and fertile
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cardiovascular system
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• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice
• however, no misdirected angiogenesis is detected
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vision/eye
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• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice
• however, no misdirected angiogenesis is detected
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cardiovascular system
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• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice
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vision/eye
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• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice
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• insufficient separation of the inner and outer nuclear layers with fewer Pax6+ cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm1Pdc mutation
(0 available);
any
Dnm1 mutation
(40 available)
Dnm2tm1.1Pdc mutation
(1 available);
any
Dnm2 mutation
(99 available)
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cellular
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• following viral delivery of Cre, fibroblasts exhibit impaired clathrin-mediated endocytosis unlike wild-type cells with increased tubulated pits and tubules
• however, cell viability in culture is normal
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