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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gstm1tm1Gcw
targeted mutation 1, George C Wagner
MGI:4456470
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gstm1tm1Gcw/Gstm1tm1Gcw involves: 129S/SvEv * C57BL/6 MGI:4456472


Genotype
MGI:4456472
hm1
Allelic
Composition
Gstm1tm1Gcw/Gstm1tm1Gcw
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• valproic acid (VPA) treatment reduces crawl-under social play behavior unlike in similarly treated wild-type mice (J:159701)
• VPA fails to decrease allogrooming or paired horizontal movement unlike in similarly treated wild-type mice (J:159701)
• valproic acid (VPA) treatment reduces crawl-under social play behavior unlike in similarly treated wild-type mice (J:159701)
• VPA fails to decrease allogrooming or paired horizontal movement unlike in similarly treated wild-type mice (J:159701)
• VPA-treated mice exhibit increased paired horizontal movement than similarly treated wild-type mice (J:159701)
• VPA-treated mice exhibit increased paired horizontal movement than similarly treated wild-type mice (J:159701)
• mice exhibit decreased paired horizontal movement compared with wild-type mice (J:159701)
• mice exhibit decreased paired horizontal movement compared with wild-type mice (J:159701)
• mice exhibit increased crawl-under social play behavior compared with wild-type mice (J:159701)
• VPA-treated mice exhibit less crawl-under social play behavior than similarly treated wild-type mice (J:159701)
• following treatment with sodium valproate at P14, female mice exhibit decreased allogrooming compared with wild-type female (J:159701)
• however, allogrooming in female and male mice is the same as in wild-type male mice (J:159701)
• mice exhibit increased crawl-under social play behavior compared with wild-type mice (J:159701)
• VPA-treated mice exhibit less crawl-under social play behavior than similarly treated wild-type mice (J:159701)
• following treatment with sodium valproate at P14, female mice exhibit decreased allogrooming compared with wild-type female (J:159701)
• however, allogrooming in female and male mice is the same as in wild-type male mice (J:159701)

nervous system
• female mice exhibit increased VPA-induced granule cell apoptosis in the cerebellum and hippocampus compared with wild-type female (J:159701)
• however, levels of apoptosis in female and male mice are the same as in wild-type male mice (J:159701)
• female mice exhibit increased VPA-induced granule cell apoptosis in the cerebellum and hippocampus compared with wild-type female (J:159701)
• however, levels of apoptosis in female and male mice are the same as in wild-type male mice (J:159701)
• mice exhibit increased cerebellum dopamine levels compared with wild-type mice (J:159701)
• male mice exhibit increased frontal cortex dopamine levels regardless of VPA treatment compared with similarly treated wild-type mice (J:159701)
• however, VPA treatment increases dopamine to levels observed in similarly treated wild-type mice (J:159701)
• mice exhibit increased cerebellum dopamine levels compared with wild-type mice (J:159701)
• male mice exhibit increased frontal cortex dopamine levels regardless of VPA treatment compared with similarly treated wild-type mice (J:159701)
• however, VPA treatment increases dopamine to levels observed in similarly treated wild-type mice (J:159701)

homeostasis/metabolism
• mice exhibit increased cerebellum dopamine levels compared with wild-type mice (J:159701)
• male mice exhibit increased frontal cortex dopamine levels regardless of VPA treatment compared with similarly treated wild-type mice (J:159701)
• however, VPA treatment increases dopamine to levels observed in similarly treated wild-type mice (J:159701)
• mice exhibit increased cerebellum dopamine levels compared with wild-type mice (J:159701)
• male mice exhibit increased frontal cortex dopamine levels regardless of VPA treatment compared with similarly treated wild-type mice (J:159701)
• however, VPA treatment increases dopamine to levels observed in similarly treated wild-type mice (J:159701)
• however, VPA treatment lowers cerebellum serotonin levels (J:159701)
• mice exhibit increased cerebellum serotonin levels compared with wild-type mice (J:159701)
• mice exhibit increased cerebellum serotonin levels compared with wild-type mice (J:159701)
• however, VPA treatment lowers cerebellum serotonin levels (J:159701)
• VPA treatment decreases cerebellum serotonin levels unlike in similarly treated wild-type mice (J:159701)
• however, VPA treatment lowers cerebellum serotonin levels and increases dopamine to levels observed in similarly treated wild-type mice (J:159701)
• VPA treatment decreases cerebellum serotonin levels unlike in similarly treated wild-type mice (J:159701)
• however, VPA treatment lowers cerebellum serotonin levels and increases dopamine to levels observed in similarly treated wild-type mice (J:159701)

cellular
• female mice exhibit increased VPA-induced granule cell apoptosis in the cerebellum and hippocampus compared with wild-type female (J:159701)
• however, levels of apoptosis in female and male mice are the same as in wild-type male mice (J:159701)
• female mice exhibit increased VPA-induced granule cell apoptosis in the cerebellum and hippocampus compared with wild-type female (J:159701)
• however, levels of apoptosis in female and male mice are the same as in wild-type male mice (J:159701)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:159701





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory