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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il6ratm1.2Drew
targeted mutation 1.2, Angela Drew
MGI:4456450
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il6ratm1.2Drew/Il6ratm1.2Drew involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:4456457
cx2
Il6tm1Kopf/Il6tm1Kopf
Il6ratm1.2Drew/Il6ratm1.2Drew
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL MGI:4456869


Genotype
MGI:4456457
hm1
Allelic
Composition
Il6ratm1.2Drew/Il6ratm1.2Drew
Genetic
Background
involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ratm1.2Drew mutation (0 available); any Il6ra mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following carrageenan induced inflammation, mice exhibit impaired neutrophil resolution after 7 days and delayed macrophage infiltration compared to in similarly treated wild-type mice

homeostasis/metabolism
• mice exhibit delayed re-epithelialization of small and large wounds is delayed compared to in wild-type mice
• mice exhibit deficits in the formation of granulation tissue at wounds compared with wild-type mice
• however, macroscopic wound closure rates are normal




Genotype
MGI:4456869
cx2
Allelic
Composition
Il6tm1Kopf/Il6tm1Kopf
Il6ratm1.2Drew/Il6ratm1.2Drew
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ratm1.2Drew mutation (0 available); any Il6ra mutation (35 available)
Il6tm1Kopf mutation (9 available); any Il6 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit delayed re-epithelialization of small and large wounds is delayed compared to in wild-type mice
• mice exhibit deficits in the formation of granulation tissue at wounds compared with wild-type mice
• however, macroscopic wound closure rates are normal





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory