All Phenotypes Hand2<tm1.2Zllr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hand2^tm1.2Zllr
targeted mutation 1.2, Rolf Zeller
MGI:4453961

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hand2^tm1.2Zllr/Hand2^tm1.2Zllr	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:4453964
cn2	Gli3^Xt-J/Gli3^Xt-J Hand2^tm1.1Zllr/Hand2^tm1.2Zllr Tg(Prrx1-cre)1Cjt/0	involves: 129 * BALB/cJ * C3H/HeJ * C57BL/6 * SJL	MGI:4453963
cn3	Hand2^tm1.1Zllr/Hand2^tm1.2Zllr Tg(Prrx1-cre)1Cjt/0	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:4453962
cx4	Hand2^tm1.2Zllr/Hand2⁺ Is(In8B2-8B3.1;6C1)1Tshir/0	involves: 129 * C57BL/6 * C57BL/10 * NZB * wild-derived	MGI:5518834
cx5	Hand2^tm1.2Zllr/Hand2^tm1.2Zllr Is(In8B2-8B3.1;6C1)1Tshir/Is(In8B2-8B3.1;6C1)1Tshir	involves: 129 * C57BL/6 * C57BL/10 * NZB * wild-derived	MGI:5518837

Allelic Composition	Hand2^tm1.2Zllr/Hand2^tm1.2Zllr
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm1.2Zllr mutation (0 available); any Hand2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

embryonic growth retardation ( J:159210 )

• growth retardation at E9.5-9.75 (25-27 somites)

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:159210 )

• malformed branchial arches at embryonic day E9.5-9.75

dilated aortic sac ( J:159210 )

• dilated aortic sac at E9.5-9.75

distended pericardium ( J:159210 )

• dilated pericardial sac at E9.5-9.75

cellular

increased embryonic tissue cell apoptosis ( J:159210 )

• massive and generalized cell death in embryos and limb buds at E9.5

craniofacial

abnormal pharyngeal arch artery morphology ( J:159210 )

• malformed branchial arches at embryonic day E9.5-9.75

embryo

abnormal pharyngeal arch artery morphology ( J:159210 )

• malformed branchial arches at embryonic day E9.5-9.75

increased embryonic tissue cell apoptosis ( J:159210 )

• massive and generalized cell death in embryos and limb buds at E9.5

embryonic growth retardation ( J:159210 )

• growth retardation at E9.5-9.75 (25-27 somites)

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Hand2^tm1.1Zllr/Hand2^tm1.2Zllr Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129 * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Hand2^tm1.1Zllr mutation (0 available); any Hand2 mutation (12 available)
Hand2^tm1.2Zllr mutation (0 available); any Hand2 mutation (12 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:159210 )

• digits with undetermined identities in forelimb autopod at E14.5

postaxial polydactyly ( J:159210 )

• extreme postaxial polydactyly in forelimb autopod at E14.5

preaxial polydactyly ( J:159210 )

• extreme preaxial polydactyly in forelimb autopod at E14.5

abnormal forelimb stylopod morphology ( J:159210 )

• shortening of the stylopod in forelimbs at E14.5

abnormal forelimb zeugopod morphology ( J:159210 )

• symmetrical forelimb zeugopodal bones and elbow joints at E14.5

abnormal limb development ( J:159210 )

• duplicated elbow-like structure in forelimbs at E14.5

• stunted forelimbs at E14.5

• little phenotypic variability

• survival of the zeugopod and autopod progenitors is restored in contrast to Tg(Prrx1-cre)1Cjt/o, Hand2^tm1.1Zllr, Hand2^tm1.2Zllr limbs

Allelic Composition	Hand2^tm1.1Zllr/Hand2^tm1.2Zllr Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm1.1Zllr mutation (0 available); any Hand2 mutation (12 available)
Hand2^tm1.2Zllr mutation (0 available); any Hand2 mutation (12 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:159210 )

• distal truncations of the forelimb skeleton and loss of the autopod in most severely affected cases at E14.5 (35%)

• fused tarsal bones in hindlimb at E14.5

abnormal forelimb zeugopod morphology ( J:159210 )

• variable skeletal phenotypes at E14.5

• shortened and fused radius and ulna in most severely affected cases (35%)

• formation of two misplaced zeugopodal bones (39%) in the most hypomorphic phenotype (weak)

• formation of one zeugopodal bone (26%) in the less hypomorphic phenotype (intermediate)

abnormal hindlimb morphology ( J:159210 )

• formation of an autopod with 4-5 digits in hindlimb at E14.5

• the formation of digit 2 and/or 3 in hindlimb is always affected

abnormal digit development ( J:159210 )

• variable skeletal phenotypes in forelimb at E14.5

• distal truncations of the forelimb skeleton and loss of the autopod in most severely affected cases at E14.5 (35%)

• formation of three anterior digits and a hypoplastic digit that resembles digit 4 (39%) in the most hypomorphic phenotype (weak) in forelimb

• formation of two digits (26%) in the less hypomorphic phenotype (intermediate) in forelimb

• formation of an autopod with 4-5 digits in hindlimb at E14.5

• the formation of digit 2 and/or 3 in hindlimb is always affected

abnormal interdigital cell death ( J:159210 )

• in the most severely affected forelimb buds, the apoptotic domain expands distal-anterior along the entire proximo-distal axis at E10.25, E10.75 and E11

cellular

abnormal interdigital cell death ( J:159210 )

• in the most severely affected forelimb buds, the apoptotic domain expands distal-anterior along the entire proximo-distal axis at E10.25, E10.75 and E11

increased apoptosis ( J:159210 )

• in the most severely affected forelimb buds, the apoptotic domain expands distal-anterior along the entire proximo-distal axis at E10.25, E10.75 and E11

Allelic Composition	Hand2^tm1.2Zllr/Hand2⁺ Is(In8B2-8B3.1;6C1)1Tshir/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/10 * NZB * wild-derived

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm1.2Zllr mutation (0 available); any Hand2 mutation (12 available)
Is(In8B2-8B3.1;6C1)1Tshir mutation (1 available); any Is(In8B2-8B3.1;6C1)1Tshir mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:198239 )

N	• mutants do not exhibit first digit deformities that are seen in Is(In8B2-8B3.1;6C1)1Tshir/0 mice

Allelic Composition	Hand2^tm1.2Zllr/Hand2^tm1.2Zllr Is(In8B2-8B3.1;6C1)1Tshir/Is(In8B2-8B3.1;6C1)1Tshir
Genetic Background	involves: 129 * C57BL/6 * C57BL/10 * NZB * wild-derived

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:198239 )

N	• mutants do not exhibit ventricular septal defect

craniofacial

abnormal craniofacial morphology ( J:198239 )

• craniofacial deformities

limbs/digits/tail

limbs/digits/tail phenotype ( J:198239 )

N	• mutants do not exhibit hemimelia or digit deformities

skeleton

clavicle hypoplasia ( J:198239 )

abnormal cervical vertebrae morphology ( J:198239 )

• cervical vertebra anomalies

growth/size/body

microcephaly ( J:198239 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23