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Allele Symbol Allele Name Allele ID |
Tg(Prnp-ITM2B*)7Jckr transgene insertion 7, Mathias Jucker MGI:4452483 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 months, mice exhibit a greater than 50-fold increase in Gallyas+ neurofibrillary pathology compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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• at 12 months, mice exhibit an 18-fold increase in neocortex Tau inclusions compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
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• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at 6 months, mice exhibit normal behavior
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• at 18 to 20 months, mice take longer to find the platform in the Morris water maze compared with wild-type mice
• during the probe trials, 18 to 20 month old mice tend to have a preference for the training target zone compared with wild-type mice
• during the two probe trials, mice exhibit a minor reduction in searching precision after 24 hours and a total loss of spatial selectivity after 6 days compared with wild-type mice
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• in Morris water maze, aged mice exhibit increased passive floating and reduced swim speed compared with wild-type mice
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• in an open field test, aged mice exhibit reduced activity, preference for the wall zone, reduced vertical activity, and more numerous fecal boli compared with wild-type mice
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• in Morris water maze and in an open field tests with aged mice
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• in Morris water maze, aged mice exhibit increased passive floating and reduced swim speed compared with wild-type mice
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• in an open field test with aged mice
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• in an open field test with aged mice
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• at 18 months, mice exhibit age-dependent, vasculature-associated Dan-amyloid deposition in the amygdala, thalamus, brainstem, and cerebellum unlike wild-type mice
• smaller vessels are often obstructed by depositions
• perivascular plaques often surround a significant portion of the vessel surface
• 18 month old mice exhibit cerebral microhemorrhages unlike in wild-type mice
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• 18 month old mice exhibit cerebral microhemorrhages unlike in wild-type mice
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• in juxtaposition to amyloid depositions
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• neuronal cell bodies in the CA3/4 region of the hippocampus are displaced compared to in wild-type mice
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• Dan-amyloid deposition elicits activation of astrocytes throughout the entire brain
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• mice exhibit dystrophic neurites unlike wild-type mice
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• Dan-amyloid lesions are associated with dystrophic boutons
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• at 18 months, mice exhibit age-dependent, vasculature-associated Dan-amyloid deposition in the amygdala, thalamus, brainstem, and cerebellum unlike wild-type mice
• smaller vessels are often obstructed by depositions
• perivascular plaques often surround a significant portion of the vessel surface
• 18 month old mice exhibit cerebral microhemorrhages unlike in wild-type mice
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• 18 month old mice exhibit cerebral microhemorrhages unlike in wild-type mice
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• at 18 months, mice are 20% to 30% lighter than wild-type mice
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• coinciding with Dan-amyloid accumulation
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• in juxtaposition to amyloid depositions
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• in juxtaposition to amyloid depositions
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• at 18 months, mice exhibit age-dependent, vasculature-associated Dan-amyloid deposition in the amygdala, thalamus, brainstem, and cerebellum unlike wild-type mice
• smaller vessels are often obstructed by depositions
• perivascular plaques often surround a significant portion of the vessel surface
• perivascular amyloid penetrates into the surrounding parenchyma and is surrounded by microglia and dystrophic neurites
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cerebral amyloid angiopathy | DOID:9246 | J:159279 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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