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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Prnp-ITM2B*)7Jckr
transgene insertion 7, Mathias Jucker
MGI:4452483
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
B6.Cg-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-MAPT*P301S)2541Godt MGI:4452491
cx2
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:4452489
tg3
Tg(Prnp-ITM2B*)7Jckr/0 C57BL/6-Tg(Prnp-ITM2B*)7Jckr MGI:4452488


Genotype
MGI:4452491
cx1
Allelic
Composition
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
Genetic
Background
B6.Cg-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-MAPT*P301S)2541Godt
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 months, mice exhibit a greater than 50-fold increase in Gallyas+ neurofibrillary pathology compared with Tg(Thy1-MAPT*P301S)2541Godt mice
• at 12 months, mice exhibit an 18-fold increase in neocortex Tau inclusions compared with Tg(Thy1-MAPT*P301S)2541Godt mice




Genotype
MGI:4452489
cx2
Allelic
Composition
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background
C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
• mice exhibit a 68% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:4452488
tg3
Allelic
Composition
Tg(Prnp-ITM2B*)7Jckr/0
Genetic
Background
C57BL/6-Tg(Prnp-ITM2B*)7Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• at 6 months, mice exhibit normal behavior
• at 18 to 20 months, mice take longer to find the platform in the Morris water maze compared with wild-type mice
• during the probe trials, 18 to 20 month old mice tend to have a preference for the training target zone compared with wild-type mice
• during the two probe trials, mice exhibit a minor reduction in searching precision after 24 hours and a total loss of spatial selectivity after 6 days compared with wild-type mice
• in Morris water maze, aged mice exhibit increased passive floating and reduced swim speed compared with wild-type mice
• in an open field test, aged mice exhibit reduced activity, preference for the wall zone, reduced vertical activity, and more numerous fecal boli compared with wild-type mice
• in Morris water maze and in an open field tests with aged mice
• in Morris water maze, aged mice exhibit increased passive floating and reduced swim speed compared with wild-type mice
• in an open field test with aged mice
• in an open field test with aged mice

nervous system
• at 18 months, mice exhibit age-dependent, vasculature-associated Dan-amyloid deposition in the amygdala, thalamus, brainstem, and cerebellum unlike wild-type mice
• smaller vessels are often obstructed by depositions
• perivascular plaques often surround a significant portion of the vessel surface
• 18 month old mice exhibit cerebral microhemorrhages unlike in wild-type mice
• 18 month old mice exhibit cerebral microhemorrhages unlike in wild-type mice
• in juxtaposition to amyloid depositions
• neuronal cell bodies in the CA3/4 region of the hippocampus are displaced compared to in wild-type mice
• Dan-amyloid deposition elicits activation of astrocytes throughout the entire brain
• mice exhibit dystrophic neurites unlike wild-type mice
• Dan-amyloid lesions are associated with dystrophic boutons

cardiovascular system
• at 18 months, mice exhibit age-dependent, vasculature-associated Dan-amyloid deposition in the amygdala, thalamus, brainstem, and cerebellum unlike wild-type mice
• smaller vessels are often obstructed by depositions
• perivascular plaques often surround a significant portion of the vessel surface
• 18 month old mice exhibit cerebral microhemorrhages unlike in wild-type mice
• 18 month old mice exhibit cerebral microhemorrhages unlike in wild-type mice

growth/size/body
• at 18 months, mice are 20% to 30% lighter than wild-type mice
• coinciding with Dan-amyloid accumulation

skeleton
• at 18 months

hematopoietic system
• in juxtaposition to amyloid depositions

immune system
• in juxtaposition to amyloid depositions

integument
• at 18 months

homeostasis/metabolism
• at 18 months, mice exhibit age-dependent, vasculature-associated Dan-amyloid deposition in the amygdala, thalamus, brainstem, and cerebellum unlike wild-type mice
• smaller vessels are often obstructed by depositions
• perivascular plaques often surround a significant portion of the vessel surface
• perivascular amyloid penetrates into the surrounding parenchyma and is surrounded by microglia and dystrophic neurites

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, Itm2b-Related, 2 117300 J:159279





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory