Mouse Genome Informatics
cx1
    Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-Csnk1d)#Mfla/0

involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice exhibit normal social and circadian behaviors (J:158611)
• mice exhibit a 40 minute delay in D-amphetamine-induced hyperlocomotion compared with similarly treated wild-type mice
• D-amphetamine-treated mice exhibit a dose dependent suppression of vertical activity unlike similarly treated wild-type mice that exhibit an increase in vertical activity
• in a dark-light choice test, mice exhibit increased rearing in the light compartment compared with wild-type mice
• in an elevated place maze, mice spend more time in the open arms than wild-type mice
• in a novelty suppressed feeding paradigm, mice exhibit shorter latency to feeding compared with wild-type mice
• however, mice exhibit normal anxiety-related behavior in an open field, forced swim, and tail suspension tests
• mice exhibit a 40 minute delay in D-amphetamine-induced hyperlocomotion compared with similarly treated wild-type mice
• D-amphetamine-treated mice exhibit a dose dependent suppression of vertical activity unlike similarly treated wild-type mice that exhibit an increase in vertical activity
• in an open field test, mice exhibit increased vertical activity compared with wild-type mice
• increased activity begins at 6 weeks of age and persists at least until 16 months of age
• however, treatment with methylphenidate or haloperidol suppresses vertical activity
• in an open field test, mice exhibit increased horizontal and vertical activity compared with wild-type mice
• increased activity begins at 6 weeks of age and persists at least until 16 months of age
• however, treatment with methylphenidate or haloperidol decreases activity levels
• in an open field box, mice fail to build a nest unlike wild-type mice

nervous system
• protein expression of dopamine receptors 1 and 2 and NMDA receptors are decreased in the striatum compared to in wild-type mice

homeostasis/metabolism
• MK801-treated mice exhibit a more rapid onset of increased horizontal activity and decreased vertical activity compared with similarly treated wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:158611