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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fzd2tm1.1Nat
targeted mutation 1.1, Jeremy Nathans
MGI:4442611
Summary 16 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fzd2tm1.1Nat/Fzd2tm1.1Nat involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5444702
hm2
 		Fzd2tm1.1Nat/Fzd2tm1.1Nat involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4838142
cx3
 		Fzd2tm1.1Nat/Fzd2tm1.1Nat
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444705
cx4
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444706
cx5
 		Dvl3tm1Awb/Dvl3+
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444711
cx6
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+ 		involves: 129 * C57BL/6 MGI:5444714
cx7
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+ 		involves: 129 * C57BL/6 MGI:5444716
cx8
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt5atm1Amc/Wnt5a+ 		involves: 129 * C57BL/6 MGI:5444718
cx9
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Vangl2Lp/Vangl2+ 		involves: 129 * C57BL/6 * LPT/LeJ MGI:5444707
cx10
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 * LPT/LeJ MGI:5444708
cx11
 		Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+ 		involves: 129 * C57BL/6 * LPT/LeJ MGI:5444719
cx12
 		Fzd1tm1.1Nat/Fzd1tm1.1Nat
Fzd2tm1.1Nat/Fzd2tm1.1Nat 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4838139
cx13
 		Fzd1tm1.1Nat/Fzd1tm1.1Nat
Fzd2tm1.1Nat/Fzd2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4838140
cx14
 		Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2tm1.1Nat 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4838141
cx15
 		Fzd2tm1.1Nat/Fzd2tm1.1Nat
Vangl2Lp/Vangl2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ MGI:4838145
cx16
 		Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ MGI:4838144


Genotype
MGI:5444702
hm1
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:189062 )
• with around 50% penetrance (25 of 53)

digestive/alimentary system
cleft palate ( J:189062 )
• with around 50% penetrance (25 of 53)

growth/size/body
cleft palate ( J:189062 )
• with around 50% penetrance (25 of 53)




Genotype
MGI:4838142
hm2
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:165556 )
• in 50% of mice despite normal prenatal survival

nervous system
nervous system phenotype ( J:165556 )
N
• olfactory bulb morphology is normal
abnormal nervous system electrophysiology ( J:165556 )
• mice exhibit reduced electro-olfactogram response to odorant stimulation compared with wild-type mice

craniofacial
cleft palate ( J:165556 )
• in 50% of mice

growth/size/body
cleft palate ( J:165556 )
• in 50% of mice
decreased body size ( J:165556 )
• in surviving mice

taste/olfaction
abnormal olfactory system physiology ( J:165556 )
• mice exhibit reduced electro-olfactogram response to odorant stimulation compared with wild-type mice

digestive/alimentary system
cleft palate ( J:165556 )
• in 50% of mice




Genotype
MGI:5444705
cx3
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2tm1.1Nat
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
disorganized yolk sac vascular plexus ( J:189062 )
• fail to develop an organized vascular plexus at E9.5
incomplete embryo turning ( J:189062 )
• fail to complete tail turning
decreased embryo size ( J:189062 )
• modest decrease in size at E8.5
abnormal embryonic tissue morphology ( J:189062 )
• strikingly rotund morphology at E8.5 (length:width ratio of around 2 compared to around 3.5 in controls)
abnormal parietal yolk sac morphology ( J:189062 )
• at E10.5 the yolk sac vasculature is engorged with blood

cardiovascular system
decreased angiogenesis ( J:189062 )
• rudimentary vasculature at E9.5
disorganized yolk sac vascular plexus ( J:189062 )
• fail to develop an organized vascular plexus at E9.5
abnormal heart development ( J:189062 )
• fail to develop left-right heart asymmetry

nervous system

growth/size/body
embryonic growth retardation ( J:189062 )
• at E8.5
decreased embryo size ( J:189062 )
• modest decrease in size at E8.5




Genotype
MGI:5444706
cx4
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:189062 )
• more than 50% die postnatally
• survivors are viable and fertile

cardiovascular system
abnormal heart morphology ( J:189062 )
• 50% of embryos (n=22) display cardiac defects
double outlet right ventricle ( J:189062 )
• DORV in combination with a ventricular septal defect is occasionally seen

craniofacial
craniofacial phenotype ( J:189062 )
N
• Background Sensitivity: no palate closure defects are detected in mice on a mixed strain background including 129 and C57BL/6; however, palate closure defects are seen in mice on a mixed strain background including 129, C57BL/6 and LPT/LeJ




Genotype
MGI:5444711
cx5
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (38 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 83% of embryos (n=12) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:5444714
cx6
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (35 available)
Wnt3atm1Amc mutation (1 available); any Wnt3a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 92% of embryos (n=12) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 14% of embryos (n=14)

digestive/alimentary system
cleft palate ( J:189062 )
• in 14% of embryos (n=14)

growth/size/body
cleft palate ( J:189062 )
• in 14% of embryos (n=14)




Genotype
MGI:5444716
cx7
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (35 available)
Wnt11tm1Amc mutation (2 available); any Wnt11 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 100% of embryos (n=10) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

digestive/alimentary system
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

growth/size/body
cleft palate ( J:189062 )
• in 11% of embryos (n=9)




Genotype
MGI:5444718
cx8
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt5atm1Amc/Wnt5a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (35 available)
Wnt5atm1Amc mutation (1 available); any Wnt5a mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
embryonic growth retardation ( J:189062 )
• starting at E9.5

embryo
embryonic growth retardation ( J:189062 )
• starting at E9.5




Genotype
MGI:5444707
cx9
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (35 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 37% of embryos (n=18) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 53% of embryos (n=17)

digestive/alimentary system
cleft palate ( J:189062 )
• in 53% of embryos (n=17)

growth/size/body
cleft palate ( J:189062 )
• in 53% of embryos (n=17)




Genotype
MGI:5444708
cx10
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:189062 )
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ

digestive/alimentary system
cleft palate ( J:189062 )
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ

growth/size/body
cleft palate ( J:189062 )
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ




Genotype
MGI:5444719
cx11
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 50% of embryos (n=6) display cardiac defects compared to 0% of embryos heterozygous for either mutation alone
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:4838139
cx12
Allelic
Composition		 Fzd1tm1.1Nat/Fzd1tm1.1Nat
Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Nat mutation (1 available); any Fzd1 mutation (29 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:165556 )
• 16 of 22 mice between E16 and E18 exhibit either ventricular septal defect (VSD), overriding aorta, double outlet right ventricle, or a combination of VSD and one of the other two defects unlike wild-type mice

craniofacial
abnormal mouth morphology ( J:165556 )
• at E16, the roof of the mouth is wider than in wild-type mice
abnormal palate development ( J:165556 )
• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
cleft palate ( J:165556 )
• in nearly all mice

embryo
embryo phenotype ( J:165556 )
N
• mice exhibit normal dorsal root ganglia and thymic rudiments indicating normal neural crest migration
• mice do not exhibit neural tube defects

hearing/vestibular/ear
abnormal cochlear hair cell morphology ( J:165556 )
• mice exhibit cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) unlike wild-type mice
abnormal orientation of outer hair cell stereociliary bundles ( J:165556 )
• most severe in outer hair cell row 3

homeostasis/metabolism
cyanosis ( J:165556 )
• at birth

nervous system
abnormal cochlear hair cell morphology ( J:165556 )
• mice exhibit cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) unlike wild-type mice
abnormal orientation of outer hair cell stereociliary bundles ( J:165556 )
• most severe in outer hair cell row 3

skeleton

digestive/alimentary system
abnormal palate development ( J:165556 )
• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
cleft palate ( J:165556 )
• in nearly all mice

growth/size/body
abnormal mouth morphology ( J:165556 )
• at E16, the roof of the mouth is wider than in wild-type mice
abnormal palate development ( J:165556 )
• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
palatal shelves fail to meet at midline ( J:165556 )
cleft palate ( J:165556 )
• in nearly all mice
failure of palatal shelf elevation ( J:165556 )
• in some mice




Genotype
MGI:4838140
cx13
Allelic
Composition		 Fzd1tm1.1Nat/Fzd1tm1.1Nat
Fzd2tm1.1Nat/Fzd2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Nat mutation (1 available); any Fzd1 mutation (29 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:165556 )
• in 1 of 8 mice

craniofacial
cleft palate ( J:165556 )
• in 2 of 208 mice

digestive/alimentary system
cleft palate ( J:165556 )
• in 2 of 208 mice

growth/size/body
cleft palate ( J:165556 )
• in 2 of 208 mice




Genotype
MGI:4838141
cx14
Allelic
Composition		 Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Nat mutation (1 available); any Fzd1 mutation (29 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:165556 )
• in 1 of 6 mice




Genotype
MGI:4838145
cx15
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2tm1.1Nat
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
open neural tube ( J:165556 )
• in all mice, more common in the caudal neural tube
abnormal cochlear hair cell morphology ( J:165556 )
• cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) are modestly more severe than in Vangl2Lp heterozygotes
abnormal orientation of outer hair cell stereociliary bundles ( J:165556 )
• most severe in outer hair cell row 3

hearing/vestibular/ear
abnormal cochlear hair cell morphology ( J:165556 )
• cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) are modestly more severe than in Vangl2Lp heterozygotes
abnormal orientation of outer hair cell stereociliary bundles ( J:165556 )
• most severe in outer hair cell row 3

cardiovascular system
ventricular septal defect ( J:165556 )
• muscular and/or membranous in mice with neural tube defects

embryo
open neural tube ( J:165556 )
• in all mice, more common in the caudal neural tube

craniofacial
cleft palate ( J:165556 )
• in 50% of mice

digestive/alimentary system
cleft palate ( J:165556 )
• in 50% of mice

growth/size/body
cleft palate ( J:165556 )
• in 50% of mice




Genotype
MGI:4838144
cx16
Allelic
Composition		 Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Nat mutation (1 available); any Fzd1 mutation (29 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (33 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
open neural tube ( J:165556 )
• in 4 of 7 mice, more common in the rostral neural tube

cardiovascular system
ventricular septal defect ( J:165556 )
• muscular and/or membranous in mice with neural tube defects

nervous system
open neural tube ( J:165556 )
• in 4 of 7 mice, more common in the rostral neural tube




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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory