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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Xirp1tm1Dofr
targeted mutation 1, Dieter O Furst
MGI:4442410
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Xirp1tm1Dofr/Xirp1tm1Dofr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4442413


Genotype
MGI:4442413
hm1
Allelic
Composition
Xirp1tm1Dofr/Xirp1tm1Dofr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xirp1tm1Dofr mutation (0 available); any Xirp1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• the body weight of older mice is lower than that of controls

cardiovascular system
N
• septum of the heart is similar to controls
• left ventricular wall thickness is similar to controls
• cardiomyocytes show a small but significant increase in length
• coronary blood vessels in young mice but not older mice show a high degree of perivascular fibrosis
• no increase in interstitial fibrosis
• stimulated cardiac myocytes show a decreased duration of shortening at all frequencies
• contraction and relaxation velocities are faster at stimulation frequencies above 6 Hz
• sarcomere shortening is decreased when stimulated at a low frequency
• a significantly shorter HV interval (interval from His to first QRS movement in surface ECG) is observed on an electrocardiogram
• there is a trend toward a shorter QRS interval on an electrocardiogram

muscle
• stimulated cardiac myocytes show a decreased duration of shortening at all frequencies
• contraction and relaxation velocities are faster at stimulation frequencies above 6 Hz
• sarcomere shortening is decreased when stimulated at a low frequency
• sarcomeres are longer than in controls





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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory