Phenotypes associated with this allele

• Allele Symbol: Xirp1^tm1Dofr
• Allele Name: targeted mutation 1, Dieter O Furst
• Allele ID: MGI:4442410
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xirp1^tm1Dofr/Xirp1^tm1Dofr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4442413

Genotype
MGI:4442413

hm1

• Allelic Composition: Xirp1^tm1Dofr/Xirp1^tm1Dofr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:159352 )

• the body weight of older mice is lower than that of controls

cardiovascular system

cardiovascular system phenotype ( J:159352 )

N • septum of the heart is similar to controls

N • left ventricular wall thickness is similar to controls

abnormal cardiovascular system morphology ( J:159352 )

abnormal myocardium layer morphology ( J:159352 )

• cardiomyocytes show a small but significant increase in length

cardiac fibrosis ( J:159352 )

• coronary blood vessels in young mice but not older mice show a high degree of perivascular fibrosis

• no increase in interstitial fibrosis

abnormal cardiovascular system physiology ( J:159352 )

abnormal cardiac muscle contractility ( J:159352 )

• stimulated cardiac myocytes show a decreased duration of shortening at all frequencies

• contraction and relaxation velocities are faster at stimulation frequencies above 6 Hz

decreased cardiac muscle contractility ( J:159352 )

• sarcomere shortening is decreased when stimulated at a low frequency

shortened HV interval ( J:159352 )

• a significantly shorter HV interval (interval from His to first QRS movement in surface ECG) is observed on an electrocardiogram

shortened QRS complex duration ( J:159352 )

• there is a trend toward a shorter QRS interval on an electrocardiogram

muscle

abnormal myocardium layer morphology ( J:159352 )

• cardiomyocytes show a small but significant increase in length

abnormal cardiac muscle contractility ( J:159352 )

• stimulated cardiac myocytes show a decreased duration of shortening at all frequencies

• contraction and relaxation velocities are faster at stimulation frequencies above 6 Hz

decreased cardiac muscle contractility ( J:159352 )

• sarcomere shortening is decreased when stimulated at a low frequency

abnormal sarcomere morphology ( J:159352 )

• sarcomeres are longer than in controls