Phenotypes associated with this allele

• Allele Symbol: Pten^tm1.1Gle
• Allele Name: targeted mutation 1.1, Gustavo Leone
• Allele ID: MGI:4442330
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pten^tm1.1Gle/Pten^tm1.1Gle	involves: 129S6/SvEvTac * Black Swiss * FVB/N	MGI:4442332
ht2	Pten^tm1.1Gle/Pten^+	involves: 129S6/SvEvTac * Black Swiss * FVB/N	MGI:4442333

Genotype
MGI:4442332

hm1

• Allelic Composition: Pten^tm1.1Gle/Pten^tm1.1Gle
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:158751 )

• resorption by E9.5

embryo

abnormal gastrulation ( J:158751 )

• failure of axial rotation

abnormal rostral-caudal axis patterning ( J:158751 )

• defects in anterior-posterior patterning

abnormal embryonic tissue morphology ( J:158751 )

• absence of overt tissue differentiation

Genotype
MGI:4442333

ht2

• Allelic Composition: Pten^tm1.1Gle/Pten⁺
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

neoplasm

increased stomach tumor incidence ( J:158751 )

• increased coincidence of stomach tumors with prostate neoplasms

increased mammary gland tumor incidence ( J:158751 )

• increased coincidence of mammary tumor in females and intestinal lesions

• increased coincidence of mammary tumor in females and adrenal lesions

increased adrenal gland tumor incidence ( J:158751 )

• 51.6% of 9 month old mice develop proliferative lesions of the adrenal gland

increased prostate gland tumor incidence ( J:158751 )

♂ • increased coincidence of stomach tumors with prostate neoplasms

increased thyroid tumor incidence ( J:158751 )

• 58.6% of 9 month old mice develop proliferative lesions of the thyroid

increased lymphoma incidence ( J:158751 )

• 54.1% of 9 month old mice develop proliferative lesions of the lymph node

increased T cell derived lymphoma incidence ( J:158751 )

• 65.0% of 9 month old mice develop proliferative lesions of the thymus

reproductive system

increased prostate gland tumor incidence ( J:158751 )

♂ • increased coincidence of stomach tumors with prostate neoplasms

endometrium hyperplasia ( J:158751 )

♀ • proliferative lesions of the endometrium, simple hyperplasia and atypical hyperplasia

integument

increased mammary gland tumor incidence ( J:158751 )

• increased coincidence of mammary tumor in females and intestinal lesions

• increased coincidence of mammary tumor in females and adrenal lesions

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:158751 )

• increased coincidence of mammary tumor in females and intestinal lesions

• increased coincidence of mammary tumor in females and adrenal lesions

increased adrenal gland tumor incidence ( J:158751 )

• 51.6% of 9 month old mice develop proliferative lesions of the adrenal gland

increased prostate gland tumor incidence ( J:158751 )

♂ • increased coincidence of stomach tumors with prostate neoplasms

increased T cell derived lymphoma incidence ( J:158751 )

• 65.0% of 9 month old mice develop proliferative lesions of the thymus

increased thyroid tumor incidence ( J:158751 )

• 58.6% of 9 month old mice develop proliferative lesions of the thyroid

digestive/alimentary system

increased stomach tumor incidence ( J:158751 )

• increased coincidence of stomach tumors with prostate neoplasms

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Cowden syndrome		DOID:6457	OMIM:PS158350	J:158751