Phenotypes associated with this allele

• Allele Symbol: Mapk8^tm1Jcbr
• Allele Name: targeted mutation 1, Jens C Bruning
• Allele ID: MGI:4441327
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mapk8^tm1Jcbr/Mapk8^tm1Jcbr Tg(Ckmm-cre)5Khn/0	involves: 129S4/SvJae * C57BL/6 * FVB	MGI:5494712
cn2	Mapk8^tm1Jcbr/Mapk8^tm1Jcbr Tg(Nes-cre)1Kln/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:4441341

Genotype
MGI:5494712

cn1

• Allelic Composition: Mapk8^tm1Jcbr/Mapk8^tm1Jcbr; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:195844 )

N • whether fed standard chow or a high fat diet, mice exhibit normal body composition

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:195844 )

N • whether fed standard chow or a high fat diet, mice exhibit normal energy homeostasis, insulin sensitivity and glucose homeostasis

Genotype
MGI:4441341

cn2

• Allelic Composition: Mapk8^tm1Jcbr/Mapk8^tm1Jcbr; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:158650 )

• in fed or fasted mice on a standard diet

decreased circulating growth hormone level ( J:158650 )

• in mice fed a standard diet

increased circulating triiodothyronine level ( J:158650 )

• in mice fed a standard diet

increased oxygen consumption ( J:158650 )

• in mice fed a high-fat diet

abnormal glucose homeostasis ( J:158650 )

decreased circulating glucose level ( J:158650 )

• in fasted and fed mice on a high-fat diet

decreased circulating insulin level ( J:158650 )

• in mice fed a standard or high-fat diet

improved glucose tolerance ( J:158650 )

• in mice fed a high-fat diet

increased insulin sensitivity ( J:158650 )

• whether fed a standard or high-fat diet, intracerebroventricular insulin treatment reduces food intake, triggers weight loss, and improves hypothalamic insulin action unlike in similarly treated wild-type mice

• mice fed a high fat diet exhibit improved performance in an insulin tolerance test compared with wild-type mice

increased circulating adiponectin level ( J:158650 )

• in mice fed a high-fat diet

decreased liver triglyceride level ( J:158650 )

• in mice fed a high-fat diet

liver/biliary system

decreased liver triglyceride level ( J:158650 )

• in mice fed a high-fat diet

decreased liver weight ( J:158650 )

• in mice fed a high-fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:158650 )

• mice fed a high-fat diet exhibit reduced hepatic triglyceride levels compared with similarly treated wild-type mice

growth/size/body

decreased body weight ( J:158650 )

• beginning at 4 weeks, mice fed a standard or high-fat diet exhibit decreased body weight compared with wild-type mice

• however, reduced body weight in response to leptin treatment is normal

weight loss ( J:158650 )

• following intracerebroventricular insulin treatment whether fed a standard or high-fat diet

decreased body length ( J:158650 )

• whether fed a standard or high-fat diet, mice exhibit reduced naso-anal length compared with similarly treated wild-type mice

• mice fed a high-fat diet fail to exhibit as much of an increase in naso-anal length as in wild-type mice

behavior/neurological

decreased food intake ( J:158650 )

• following intracerebroventricular insulin treatment whether fed a standard or high-fat diet

• however, decreased food intake induced by leptin treatment is normal