All Phenotypes Bhlhe22<tm2.1Meg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bhlhe22^tm2.1Meg
targeted mutation 2.1, Michael E Greenberg
MGI:4440744

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Tg(PLAT-cre)116Sdu/0	involves: 129	MGI:4440932
cn2	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Tg(Pax2-cre)1Akg/0	involves: 129	MGI:4440933
cn3	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Tlx3^tm1(cre)Qima/Tlx3⁺	involves: 129	MGI:4440934
cn4	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	MGI:5315767
cn5	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Emx1^tm1(cre)Krj/Emx1⁺	involves: 129/Sv * 129S2/SvPas	MGI:4440904
cn6	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129/Sv * C57BL/6J * CBA/J	MGI:4440902
cn7	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Tg(Nes-cre)1Kln/0	involves: 129/Sv * C57BL/6 * SJL	MGI:4440899

Allelic Composition	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Tg(PLAT-cre)116Sdu/0
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm2.1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Tg(PLAT-cre)116Sdu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:158273 )

N	• mice do not show skin lesions

integument

integument phenotype ( J:158273 )

N	• mice do not show skin lesions in response to selective deletion in neural-crest derived cells

Allelic Composition	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Tg(Pax2-cre)1Akg/0
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm2.1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Tg(Pax2-cre)1Akg mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

excessive scratching ( J:158273 )

• resulting in skin lesions in most animals

abnormal chemical nociception ( J:158273 )

• mice show excessive scratching in response to pruritic agents

integument

skin lesions ( J:158273 )

• animals display self-inflicted skin lesions

Allelic Composition	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Tlx3^tm1(cre)Qima/Tlx3⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm2.1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Tlx3^tm1(cre)Qima mutation (0 available); any Tlx3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:158273 )

N	• mice do not show skin lesions or heightened itch responses to pruritic agents

integument

integument phenotype ( J:158273 )

N	• mice do not show skin lesions in response to selective deletion in excitatory neurons in dorsal horn

Allelic Composition	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm2.1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent corpus callosum ( J:182304 )

absent hippocampal commissure ( J:182304 )

abnormal anterior corticospinal tract morphology ( J:182304 )

• mice exhibit a reduction of the corticospinal tract compared with wild-type mice

Allelic Composition	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129/Sv * 129S2/SvPas

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:158273 )

N	• mice do not show skin lesions

integument

integument phenotype ( J:158273 )

N	• mice do not show skin lesions to selective deletion in the dorsal telencephalon

Allelic Composition	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129/Sv * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm2.1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

excessive scratching ( J:158273 )

• mice show excessive scratching in response to pruritic agent compound 48/80

abnormal chemical nociception ( J:158273 )

• mice show excessive scratching in response to pruritic agent compound 48/80

integument

skin lesions ( J:158273 )

• animals display self-inflicted skin lesions, identical in frequency, location, and severity to those observed in Bhlhe22^tm1Meg homozygotes

Allelic Composition	Bhlhe22^tm2.1Meg/Bhlhe22^tm2.1Meg Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22^tm2.1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

excessive scratching ( J:158273 )

• resulting in skin lesions in most animals

integument

skin lesions ( J:158273 )

• animals display self-inflicted skin lesions

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