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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bhlhe22tm2.1Meg
targeted mutation 2.1, Michael E Greenberg
MGI:4440744
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tg(PLAT-cre)116Sdu/0
involves: 129 MGI:4440932
cn2
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tg(Pax2-cre)1Akg/0
involves: 129 MGI:4440933
cn3
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tlx3tm1(cre)Qima/Tlx3+
involves: 129 MGI:4440934
cn4
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J MGI:5315767
cn5
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Emx1tm1(cre)Krj/Emx1+
involves: 129/Sv * 129S2/SvPas MGI:4440904
cn6
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6J * CBA/J MGI:4440902
cn7
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tg(Nes-cre)1Kln/0
involves: 129/Sv * C57BL/6 * SJL MGI:4440899


Genotype
MGI:4440932
cn1
Allelic
Composition
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tg(PLAT-cre)116Sdu/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (8 available)
Tg(PLAT-cre)116Sdu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not show skin lesions

integument
N
• mice do not show skin lesions in response to selective deletion in neural-crest derived cells




Genotype
MGI:4440933
cn2
Allelic
Composition
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tg(Pax2-cre)1Akg/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (8 available)
Tg(Pax2-cre)1Akg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• resulting in skin lesions in most animals
• mice show excessive scratching in response to pruritic agents

integument
• mice show excessive scratching in response to pruritic agents
• animals display self-inflicted skin lesions




Genotype
MGI:4440934
cn3
Allelic
Composition
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tlx3tm1(cre)Qima/Tlx3+
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (8 available)
Tlx3tm1(cre)Qima mutation (0 available); any Tlx3 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not show skin lesions or heightened itch responses to pruritic agents

integument
N
• mice do not show skin lesions in response to selective deletion in excitatory neurons in dorsal horn




Genotype
MGI:5315767
cn4
Allelic
Composition
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Emx1tm1(cre)Krj/Emx1+
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (8 available)
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit a reduction of the corticospinal tract compared with wild-type mice




Genotype
MGI:4440904
cn5
Allelic
Composition
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Emx1tm1(cre)Krj/Emx1+
Genetic
Background
involves: 129/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (8 available)
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not show skin lesions

integument
N
• mice do not show skin lesions to selective deletion in the dorsal telencephalon




Genotype
MGI:4440902
cn6
Allelic
Composition
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129/Sv * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (8 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show excessive scratching in response to pruritic agent compound 48/80
• mice show excessive scratching in response to pruritic agent compound 48/80

integument
• mice show excessive scratching in response to pruritic agent compound 48/80
• animals display self-inflicted skin lesions, identical in frequency, location, and severity to those observed in Bhlhe22tm1Meg homozygotes




Genotype
MGI:4440899
cn7
Allelic
Composition
Bhlhe22tm2.1Meg/Bhlhe22tm2.1Meg
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm2.1Meg mutation (0 available); any Bhlhe22 mutation (8 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• resulting in skin lesions in most animals

integument
• animals display self-inflicted skin lesions





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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory