About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-Sncg)HvP36Putt
transgene insertion HvP36, Herman van der Putten
MGI:4440514
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Thy1-Sncg)HvP36Putt/Tg(Thy1-Sncg)HvP36Putt C57BL/6-Tg(Thy1-Sncg)HvP36Putt MGI:4440540
tg2
Tg(Thy1-Sncg)HvP36Putt/0 C57BL/6-Tg(Thy1-Sncg)HvP36Putt MGI:4440541
tg3
Tg(Thy1-Sncg)HvP36Putt/? C57BL/6-Tg(Thy1-Sncg)HvP36Putt MGI:5431238


Genotype
MGI:4440540
tg1
Allelic
Composition
Tg(Thy1-Sncg)HvP36Putt/Tg(Thy1-Sncg)HvP36Putt
Genetic
Background
C57BL/6-Tg(Thy1-Sncg)HvP36Putt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-Sncg)HvP36Putt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive beyond 16 months (J:147580)
• mice do not survive beyond 16 months (J:147580)

behavior/neurological
• at 6 to 9 months (J:147580)
• at 6 to 9 months (J:147580)
• following paresis (J:147580)
• following paresis (J:147580)
• earlier than 6 months (J:147580)
• earlier than 6 months (J:147580)
• earlier than 6 months (J:147580)
• earlier than 6 months (J:147580)
• at 6 to 9 months (J:147580)
• at 6 to 9 months (J:147580)
• at 6 to 9 months (J:147580)
• at 6 to 9 months (J:147580)
• at 6 months (J:147580)
• at 6 months (J:147580)
• following paresis (J:147580)
• following paresis (J:147580)
• at 9 to 16 months, mice develop paresis unlike wild-type mice with earlier development in forelimbs than in hindlimbs (J:147580)
• at 9 to 16 months, mice develop paresis unlike wild-type mice with earlier development in forelimbs than in hindlimbs (J:147580)

nervous system
• mice exhibit aggregation and fibrillation of gamma-synuclein in the nervous system unlike wild-type mice (J:147580)
• abnormal gamma-synuclein structures are most abundant in the spinal cord (J:147580)
• mice exhibit aggregation and fibrillation of gamma-synuclein in the nervous system unlike wild-type mice (J:147580)
• abnormal gamma-synuclein structures are most abundant in the spinal cord (J:147580)
• in the spinal cord gray matter of severely affected and older mice (J:147580)
• in the spinal cord gray matter of severely affected and older mice (J:147580)
• at 12 months, motor neuron numbers in severely affected mice are less than 40% of wild-type (J:147580)
• motor neuron loss corresponds to severity of motor impairment (J:147580)
• at 12 months, motor neuron numbers in severely affected mice are less than 40% of wild-type (J:147580)
• motor neuron loss corresponds to severity of motor impairment (J:147580)

homeostasis/metabolism
• in the spinal cord or brain tissue when mild clinical signs of pathology are apparent (J:147580)
• the number of inclusions increases as clinical phenotypes worsen (J:147580)
• in the spinal cord or brain tissue when mild clinical signs of pathology are apparent (J:147580)
• the number of inclusions increases as clinical phenotypes worsen (J:147580)




Genotype
MGI:4440541
tg2
Allelic
Composition
Tg(Thy1-Sncg)HvP36Putt/0
Genetic
Background
C57BL/6-Tg(Thy1-Sncg)HvP36Putt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-Sncg)HvP36Putt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice develop motor dysfunction compared with wild-type mice with greater latency and slower progression than homozygous mice (J:147580)
• mice develop motor dysfunction compared with wild-type mice with greater latency and slower progression than homozygous mice (J:147580)
• after 18 months of age, mice exhibit impaired performance on a rotarod compared with wild-type mice (J:147580)
• after 18 months of age, mice exhibit impaired performance on a rotarod compared with wild-type mice (J:147580)
• at 18 months, mice have shorter strides than wild-type mice (J:147580)
• at 18 months, mice have shorter strides than wild-type mice (J:147580)

nervous system
• in older mice (J:147580)
• in older mice (J:147580)
• motor neuron loss corresponds to severity of motor impairment (J:147580)
• motor neuron loss corresponds to severity of motor impairment (J:147580)

homeostasis/metabolism
• in the spinal cord or brain tissue when mild clinical signs of pathology are apparent (J:147580)
• the number of inclusions increases as clinical phenotypes worsen (J:147580)
• in the spinal cord or brain tissue when mild clinical signs of pathology are apparent (J:147580)
• the number of inclusions increases as clinical phenotypes worsen (J:147580)




Genotype
MGI:5431238
tg3
Allelic
Composition
Tg(Thy1-Sncg)HvP36Putt/?
Genetic
Background
C57BL/6-Tg(Thy1-Sncg)HvP36Putt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-Sncg)HvP36Putt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• retinal ganglion cells do not exhibit deterioration or loss despite overexpression of gamma-synuclein (J:185793)
• retinal ganglion cells do not exhibit deterioration or loss despite overexpression of gamma-synuclein (J:185793)
• gliosis is observed within motor regions of cortex (J:185793)
• gliosis is observed within motor regions of cortex (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• loss of motor neurons is observed in the trigeminal motor nucleus, but not in the facial and abducens motor nuclei (J:185793)
• neuron loss is observed in select upper and lower motor neuron populations of the motor cortex, and to a lesser degree in the somatosensory regions (J:185793)
• neuron loss is correlated with perikaryal and axonal accumulation of gamma-synuclein, accumulation of detergent-insoluble species and gliosis (J:185793)
• loss of motor neurons is observed in the trigeminal motor nucleus, but not in the facial and abducens motor nuclei (J:185793)
• neuron loss is observed in select upper and lower motor neuron populations of the motor cortex, and to a lesser degree in the somatosensory regions (J:185793)
• neuron loss is correlated with perikaryal and axonal accumulation of gamma-synuclein, accumulation of detergent-insoluble species and gliosis (J:185793)
• damage to myelin sheath is observed in substantial numbers of myelinated fibers from the sciatic nerve in severely affected mice (J:185793)
• damage to myelin sheath is observed in substantial numbers of myelinated fibers from the sciatic nerve in severely affected mice (J:185793)
• selective neuronal dystrophy is observed in the cortex (J:185793)
• selective neuronal dystrophy is observed in the cortex (J:185793)
• significant neuron loss is observed in affected 12 month old mice (J:185793)
• mice exhibit high levels of astrogliosis and microgliosis in the trigeminal motor nucleus (J:185793)
• significant neuron loss is observed in affected 12 month old mice (J:185793)
• mice exhibit high levels of astrogliosis and microgliosis in the trigeminal motor nucleus (J:185793)
• some abnormal myelinated fibers and phagocytes are observed in the dorsal spinal root (J:185793)
• however, the majority of myelinated fibers are similar to control in number and condition (J:185793)
• some abnormal myelinated fibers and phagocytes are observed in the dorsal spinal root (J:185793)
• however, the majority of myelinated fibers are similar to control in number and condition (J:185793)
• deterioration and loss of myelinated axons in severely affected mice (J:185793)
• reduction in total numbers of myelinated fibers in severely affected mice (J:185793)
• reduced levels of neurofilament proteins, alpha tubulin, and myelin basic protein are observed in severely affected mice (J:185793)
• active Wallerian-like degeneration of the sciatic nerve is observed (J:185793)
• mildly affected mice exhibit slight changes in morphology, but no loss of fibers (J:185793)
• deterioration and loss of myelinated axons in severely affected mice (J:185793)
• reduction in total numbers of myelinated fibers in severely affected mice (J:185793)
• reduced levels of neurofilament proteins, alpha tubulin, and myelin basic protein are observed in severely affected mice (J:185793)
• active Wallerian-like degeneration of the sciatic nerve is observed (J:185793)
• mildly affected mice exhibit slight changes in morphology, but no loss of fibers (J:185793)
• deterioration and loss of myelinated fibers in severely affected mice (J:185793)
• significant decrease in mean myelinated fiber size (49.5%) found in remaining myelinated fibers (J:185793)
• extensive phagocyte infiltration (J:185793)
• deterioration and loss of myelinated fibers in severely affected mice (J:185793)
• significant decrease in mean myelinated fiber size (49.5%) found in remaining myelinated fibers (J:185793)
• extensive phagocyte infiltration (J:185793)

hematopoietic system
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)

immune system
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)
• observed in the trigeminal motor nucleus in affected 12 month old mice (J:185793)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:185793





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory