mortality/aging
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|
(J:152966)
|
nervous system
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• in the germinal layers
(J:152966)
|
|
|
• at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice
(J:152966)
• at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice
(J:152966)
• at E18.5, the length of the cycle is lengthened compared to in wild-type cells
(J:152966)
|
|
|
• brains contain ectopic cellular clusters in differentiated striatal regions unlike in wild-type mice
(J:152966)
• however, no abnormalities are observed at E15.5
(J:152966)
|
|
|
(J:152966)
|
|
|
• poorly developed
(J:152966)
|
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|
• the cortex exhibits an increase in cellular density and decrease in intervening neuropil compared to in wild-type mice
(J:152966)
|
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• laminar organization is altered with no clearly identifiable superficial neuron layers compared to in wild-type mice
(J:152966)
|
|
|
(J:152966)
|
|
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• very small
(J:152966)
|
cellular
|
|
• in the germinal layers
(J:152966)
|
|
|
• at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice
(J:152966)
• at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice
(J:152966)
• at E18.5, the length of the cycle is lengthened compared to in wild-type cells
(J:152966)
|
