Mouse Genome Informatics
cn1
    Huwe1tm1Alas/Y
Tg(Nes-cre)1Kag/0

involves: 129S7/SvEvBrd
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• in the germinal layers
• at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice
• at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice
• at E18.5, the length of the cycle is lengthened compared to in wild-type cells
• brains contain ectopic cellular clusters in differentiated striatal regions unlike in wild-type mice
• however, no abnormalities are observed at E15.5
• the cortex exhibits an increase in cellular density and decrease in intervening neuropil compared to in wild-type mice
• laminar organization is altered with no clearly identifiable superficial neuron layers compared to in wild-type mice
• very small

cellular
• in the germinal layers
• at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice
• at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice
• at E18.5, the length of the cycle is lengthened compared to in wild-type cells