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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Huwe1tm1Alas
targeted mutation 1, Anna Lasorella
MGI:4439480
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Huwe1tm1Alas/Y
Tg(Nes-cre)1Kag/0
involves: 129S7/SvEvBrd MGI:4821353


Genotype
MGI:4821353
cn1
Allelic
Composition
Huwe1tm1Alas/Y
Tg(Nes-cre)1Kag/0
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Alas mutation (0 available); any Huwe1 mutation (61 available)
Tg(Nes-cre)1Kag mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice
• at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice
• at E18.5, the length of the cycle is lengthened compared to in wild-type cells
• brains contain ectopic cellular clusters in differentiated striatal regions unlike in wild-type mice
• however, no abnormalities are observed at E15.5
• the cortex exhibits an increase in cellular density and decrease in intervening neuropil compared to in wild-type mice
• laminar organization is altered with no clearly identifiable superficial neuron layers compared to in wild-type mice
• very small
• in the germinal layers

cellular
• at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice
• at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice
• at E18.5, the length of the cycle is lengthened compared to in wild-type cells





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory