Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1tm1Cgr mutation
(5 available);
any
Fmr1 mutation
(28 available)
Tg(ACTB-Eif4e)#Ppp mutation
(0 available)
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behavior/neurological
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• mice exhibit impaired contextual fear memory, spending less time freezing in a context in which they received 2 tone-shock pairs
• however, mice show normal cued fear memory
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• in the Morris water maze, mice show mildly impaired spatial learning and memory, showing fewer platform crossings during the training phase and on day 4 of the probe trial, but not on day 7
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• mice exhibit anxiety-like behavior in the elevated plus maze, making fewer open arm entries and having a lower ratio of open arm entries to total arm entries
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• in the novel object recognition task, mice do not exhibit a preference for the novel object over a familiar object as is seen in wild-type mice
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• mice are hyperactive in the open field
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• mice display stereotypic behavior in the marble burying task, burying more marbles and at a faster rate
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• mice show deficits in social interaction, with mice showing no preference for the stranger mouse versus an inanimate object as seen in wild-type mice
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nervous system
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• mice exhibit higher levels of protein synthesis in the brain than wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-Eif4e)#Ppp mutation
(0 available)
Tg(IghMyc)22Bri mutation
(1 available)
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neoplasm
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• onset of lymphoma is accelerated compared to single Tg(IghMyc)22Bri transgenic mice and is evident at less than 1 month of age
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cellular
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• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice
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immune system
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• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice
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hematopoietic system
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• reduction in apoptosis of splenic B cells at 3 weeks of age, before lymphoma occurrence, compared to single Tg(IghMyc)22Bri transgenic mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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behavior/neurological
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• mice are hyperactive in the open field
• however, mice exhibit normal anxiety in the elevated plus maze, normal novel object recognition, spatial learning and contextual fear conditioning
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• mice display stereotypic behavior in the marble burying task, burying more marbles and at a faster rate
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• mice show deficits in social interaction, with mice showing no preference for the stranger mouse versus an inanimate object as seen in wild-type mice
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nervous system
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• mice exhibit higher levels of protein synthesis in the brain
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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behavior/neurological
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• although learning ability in the acquisition and memory phases of the water-based Y maze and modified Morris water maze tasks are intact, males are impaired in locating the new platform positions in the reversal phases
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• mutants exhibit increased self grooming
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• males exhibit mild hyperactivity, however no impairments in motor coordination, motor learning and sensorimotor gating
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• males exhibit repetitive digging behavior in the marble-burying test
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• males do not show a preference for a nonspecific stranger versus a new, inanimate object
• males exhibit diminished reciprocal interactions with a freely moving stranger mouse
• treatment with 4DGI-1, an inhibitor of Eif4e-Eif4g interactions, results in a decrease in repetitive behaviors, perseverative behaviors, and in social behavior deficits
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nervous system
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• about 12% increase in spine density and smaller spine volume in layer 2/3 medial prefrontal cortex pyramidal neurons
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• mutants exhibit an increase in the frequency, but not amplitude, of miniature excitatory postsynaptic currents in layers 2/3 of acute medial prefrontal cortex slices
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• mutants exhibit an increase in the amplitude, but not frequency, of miniature inhibitory postsynaptic currents in layers 2/3 of acute medial prefrontal cortex slices
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• mutants exhibit enhanced long-term depression in the striatum
• mutants exhibit enhanced hippocampal metabotropic glutamate receptor dependent (mGluR)-long-term depression
• treatment with 4DGI-1, an inhibitor of Eif4e-Eif4g interactions, normalizes the enhanced striatal long term depression
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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neoplasm
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• mutants exhibit an increase in tumorigenesis beginning at 16 months of age
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• 21% of tumors are hepatocellular adenomas
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• 16% of tumors are B-cell lymphomas
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• 21% of tumors are lung adenocarcinomas
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• 13% of tumors are angiosarcomas
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cellular
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• mutants exhibit an increase in senescence-associated beta-galactosidase staining of splenic B cells, indicating increased senescence of splenic B cells at 3 weeks of age
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liver/biliary system
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• 21% of tumors are hepatocellular adenomas
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respiratory system
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• 21% of tumors are lung adenocarcinomas
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Analysis Tools