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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-AppDutch)#Jckr
transgene insertion, Mathias Jucker
MGI:4438890
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-AppDutch)#Jckr/0
FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-AppDutch)#Jckr MGI:5301411
cx2
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0
FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr MGI:5301410
cx3
Abcg2tm1Ahs/Abcg2tm1Ahs
Tg(Thy1-AppDutch)#Jckr/0
FVB.Cg-Abcg2tm1Ahs Tg(Thy1-AppDutch)#Jckr MGI:5301412
cx4
Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-BACE1)54/4Ppa/0
involves: C57BL/6 MGI:4819593
cx5
Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-PSEN1*G384A)45Jckr/0
involves: C57BL/6 * C57BL/6J * DBA/2 MGI:4819108
cx6
Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-PSEN1*G384A)45Jckr/0
involves: C57BL/6 * DBA/2 MGI:4819594
tg7
Tg(Thy1-AppDutch)#Jckr/0 involves: C57BL/6J MGI:4819110


Genotype
MGI:5301411
cx1
Allelic
Composition
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-AppDutch)#Jckr/0
Genetic
Background
FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-AppDutch)#Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (39 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (37 available)
Tg(Thy1-AppDutch)#Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

homeostasis/metabolism
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice




Genotype
MGI:5301410
cx2
Allelic
Composition
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0
Genetic
Background
FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc1tm1Bor mutation (0 available); any Abcc1 mutation (35 available)
Tg(Thy1-AppDutch)#Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

homeostasis/metabolism
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:178230




Genotype
MGI:5301412
cx3
Allelic
Composition
Abcg2tm1Ahs/Abcg2tm1Ahs
Tg(Thy1-AppDutch)#Jckr/0
Genetic
Background
FVB.Cg-Abcg2tm1Ahs Tg(Thy1-AppDutch)#Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg2tm1Ahs mutation (2 available); any Abcg2 mutation (54 available)
Tg(Thy1-AppDutch)#Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

homeostasis/metabolism
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice




Genotype
MGI:4819593
cx4
Allelic
Composition
Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-BACE1)54/4Ppa/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

homeostasis/metabolism
• extensive vascular amyloid in the thalamus
• parenchymal amyloid in the cortex and some amyloid in the subiculum

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:162531




Genotype
MGI:4819108
cx5
Allelic
Composition
Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-PSEN1*G384A)45Jckr/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus
• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions

homeostasis/metabolism
• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus
• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:92796




Genotype
MGI:4819594
cx6
Allelic
Composition
Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-PSEN1*G384A)45Jckr/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

homeostasis/metabolism
• massive parenchymal amyloidosis is observed throughout the entire brain with the exception of the cerellebum
• modest vascular amyloid also present




Genotype
MGI:4819110
tg7
Allelic
Composition
Tg(Thy1-AppDutch)#Jckr/0
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system

immune system

nervous system
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels

cardiovascular system
• amyloid-laden vessels show a severe loss of smooth muscle cells
• fresh hemorrhages, as well as indications of previous hemorrhages are found

muscle
• amyloid-laden vessels show a severe loss of smooth muscle cells

cellular
• an irregular thickening of the basement membrane with amorphous material in some vessels
• amyloid fibrils within the basement membrane, predominantly on the adventitial side

homeostasis/metabolism
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:92796 , J:162531





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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory