• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy

• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy

• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

• extensive vascular amyloid in the thalamus

• parenchymal amyloid in the cortex and some amyloid in the subiculum

• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus

• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions

• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus

• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions

• massive parenchymal amyloidosis is observed throughout the entire brain with the exception of the cerellebum

• modest vascular amyloid also present

• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels

• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)

• an irregular thickening of the basement membrane with amorphous material in some vessels

• amyloid fibrils within the basement membrane, predominantly on the adventitial side

• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels

• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)

• amyloid-laden vessels show a severe loss of smooth muscle cells

• fresh hemorrhages, as well as indications of previous hemorrhages are found

• amyloid-laden vessels show a severe loss of smooth muscle cells