Mouse Genome Informatics
cx1
    Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-AppDutch)#Jckr/0

FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-AppDutch)#Jckr
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

other phenotype
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice


Mouse Genome Informatics
cx2
    Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0

FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

other phenotype
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

homeostasis/metabolism

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:178230


Mouse Genome Informatics
cx3
    Abcg2tm1Ahs/Abcg2tm1Ahs
Tg(Thy1-AppDutch)#Jckr/0

FVB.Cg-Abcg2tm1Ahs Tg(Thy1-AppDutch)#Jckr
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

other phenotype
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice


Mouse Genome Informatics
cx4
    Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-BACE1)54/4Ppa/0

involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
other phenotype
• extensive vascular amyloid in the thalamus
• parenchymal amyloid in the cortex and some amyloid in the subiculum

nervous system

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:162531


Mouse Genome Informatics
cx5
    Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-PSEN1*G384A)45Jckr/0

involves: C57BL/6 * C57BL/6J * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus
• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions

other phenotype
• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus
• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:92796


Mouse Genome Informatics
cx6
    Tg(Thy1-AppDutch)#Jckr/0
Tg(Thy1-PSEN1*G384A)45Jckr/0

involves: C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
other phenotype
• massive parenchymal amyloidosis is observed throughout the entire brain with the exception of the cerellebum
• modest vascular amyloid also present

nervous system


Mouse Genome Informatics
tg7
    Tg(Thy1-AppDutch)#Jckr/0
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system

immune system

nervous system
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)

other phenotype
• an irregular thickening of the basement membrane with amorphous material in some vessels
• amyloid fibrils within the basement membrane, predominantly on the adventitial side
• cerebrovascular amyloid restricted to leptomeningeal and cortical vessels
• vascular amyloid deposition at approximately 22-25 months with female mice having an earlier onset than males (J:92796)

cardiovascular system
• amyloid-laden vessels show a severe loss of smooth muscle cells
• fresh hemorrhages, as well as indications of previous hemorrhages are found

muscle
• amyloid-laden vessels show a severe loss of smooth muscle cells

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:92796 , J:162531