Phenotypes associated with this allele

• Allele Symbol: Dnm1l^tm1.1Miha
• Allele Name: targeted mutation 1.1, Katsuyoshi Mihara
• Allele ID: MGI:4438630
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dnm1l^tm1.1Miha/Dnm1l^tm1.1Miha Tg(Nes-cre)1Kln/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:4438714

Genotype
MGI:4438714

cn1

• Allelic Composition: Dnm1l^tm1.1Miha/Dnm1l^tm1.1Miha; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:158142 )

• mice die within days of birth

craniofacial

abnormal posterior cranial fossa morphology ( J:158142 )

• at E18.5, subdural and subarachnoid spaces in the posterior fossa are enlarged compared to in wild-type mice

nervous system

increased neuron apoptosis ( J:158142 )

• at E18.5, mice exhibit an increase in apoptotic neurons in the brain compared to in wild-type mice

abnormal brain morphology ( J:158142 )

• at E15.5, mice exhibit milder brain defects than at E18.5

• at E18.5, subdural and subarachnoid spaces in the posterior fossa are enlarged compared to in wild-type mice

forebrain hypoplasia ( J:158142 )

• at E18.5

enlarged brain ventricles ( J:158142 )

• enlarged at E18.5

abnormal brain white matter morphology ( J:158142 )

• at E18.5, mice exhibit white matter hypoplasia compared with wild-type mice

• mice exhibit periventricular leukomalia unlike wild-type mice

abnormal brainstem morphology ( J:158142 )

• small at E20

small cerebellum ( J:158142 )

• at E20

abnormal subarachnoid space morphology ( J:158142 )

• at E18.5, subarachnoid spaces in the posterior fossa are enlarged compared to in wild-type mice

decreased CNS synapse formation ( J:158142 )

• cultured neuronal progenitor cells from E17.5 exhibit compromised synapse formation compared with similarly treated wild-type cells

abnormal neurite morphology ( J:158142 )

• cultured neurons exhibit fewer neurites and neurite branches compared with wild-type cells

skeleton

abnormal posterior cranial fossa morphology ( J:158142 )

• at E18.5, subdural and subarachnoid spaces in the posterior fossa are enlarged compared to in wild-type mice

cellular

abnormal mitochondrial morphology ( J:158142 )

• in cultured forebrain cells, mitochondria are decreased in number, irregularly localized within the cell body, and heterogenously localized in large clumps in the neurites unlike in wild-type cells

increased neuron apoptosis ( J:158142 )

• at E18.5, mice exhibit an increase in apoptotic neurons in the brain compared to in wild-type mice