All Phenotypes Prpf31<tm1.1Bha> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prpf31^tm1.1Bha
targeted mutation 1.1, Shomi Bhattacharya
MGI:4438621

Summary

2 genotypes

Allelic Composition	Prpf31^tm1.1Bha/Prpf31^tm1.1Bha
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prpf31^tm1.1Bha mutation (0 available); any Prpf31 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• no mice are produced (no time point given)

Allelic Composition	Prpf31^tm1.1Bha/Prpf31⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prpf31^tm1.1Bha mutation (0 available); any Prpf31 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

• loss of the basal infoldings and accumulation of amorphous deposits between the RPE and Bruch's membrane are seen at 12 months of age

retina degeneration ( J:171561 )

• late onset degeneration of the retinal pigment epithelium

pigmentation

• loss of the basal infoldings and accumulation of amorphous deposits between the RPE and Bruch's membrane are seen at 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 11		DOID:0110408	OMIM:600138	J:171561

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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