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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-TARDBP)6Singh
transgene insertion 6, Samir Kumar-Singh
MGI:4438491
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh involves: C57BL/6 * C57BL/6J * SJL MGI:4438493


Genotype
MGI:4438493
tg1
Allelic
Composition
Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh
Genetic
Background
involves: C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average survival of 6.7 months

behavior/neurological
• develops abnormal limb reflex at 2 months
• shows up to 6 fold reduced motor performance at about 4 months of age

nervous system
• increase level of activated caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP)
• decreased number of neurons in the lumbosacral region.
• highly transgene dose dependent
• large neuronal cytoplasmic and intranuclear inclusions are present to some extent in hippocampal/subicular neurons
• neuronal loss is seen in all affected brain regions
• large neuronal cytoplasmic and intranuclear inclusions are present to some extent in hippocampal/subicular neurons
• neuronal loss is seen in all affected brain regions
• large neuronal cytoplasmic and intranuclear inclusions are present in cortical layer V of the anterior cortex including the primary motor cortex
• neuronal loss is seen in all affected brain regions including both the superficial and deep cortical layers of the anterior cortex
• large neuronal cytoplasmic and intranuclear inclusions are present in somatosensory areas of the hind- and forelimbs
• neuronal loss is seen in all affected brain regions
• highly transgene dose dependent
• neuronal loss is seen in all affected brain regions including both the superficial and deep cortical layers of the anterior cortex
• present in cortical layer V of the anterior cortex including the primary motor cortex and somatosensory areas of the hind- and forelimbs and to some extent in the hippocampal/subicular neurons
• number of neurons in the lumbosacral region is significantly lower
• quantitative neuronal loss is shown in motor cortex at 6 months
• number of neurons in the lumbosacral region of the spinal cord is significantly lower
• atrophy and increased number of pyknotic neurons in the ventral horn region of the lumbosacral and cervical spinal cord occurs in a transgene dose dependent manner

hematopoietic system
• highly transgene dose dependent

immune system
• highly transgene dose dependent

cellular
• increase level of activated caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP)
• decreased number of neurons in the lumbosacral region.





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory