Phenotypes associated with this allele

• Allele Symbol: Dkkl1^tm1.1Mldp
• Allele Name: targeted mutation 1.1, Melvin DePamphilis
• Allele ID: MGI:4438465
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dkkl1^tm1.1Mldp/Dkkl1^tm1.1Mldp	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4438488
hm2	Dkkl1^tm1.1Mldp/Dkkl1^tm1.1Mldp	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:4438489

Genotype
MGI:4438488

hm1

• Allelic Composition: Dkkl1^tm1.1Mldp/Dkkl1^tm1.1Mldp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:158271 )

N • mice exhibit normal fecundity

delayed fertilization ( J:158271 )

• fertilization of wild-type eggs by sperm in vivo is delayed compared to when wild-type sperm is used

decreased fertilization frequency ( J:158271 )

• in an in vitro fertilization assay, sperm fertilize 2% of cumulus-intact eggs compared with 67% fertilization by wild-type sperm

• however, removal of the zona pellucida improves fertilization to 46%

impaired sperm penetration of zona pellucida ( J:158271 )

• in vivo and in vitro penetration of the zona pellucida by sperm is delayed compared to wild-type sperm

Genotype
MGI:4438489

hm2

• Allelic Composition: Dkkl1^tm1.1Mldp/Dkkl1^tm1.1Mldp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

reproductive system

reproductive system phenotype ( J:158272 )

N • mice exhibit normal reproduction by natural mating