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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTB-APP*V717F)1Colm
transgene insertion 1, Colin L Masters
MGI:4438112
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(ACTB-APP*V717F)1Colm/0 involves: C57BL/6 * DBA MGI:4438223


Genotype
MGI:4438223
tg1
Allelic
Composition
Tg(ACTB-APP*V717F)1Colm/0
Genetic
Background
involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• amphetamine-treated mice exhibit increased hyperactivity compared with similarly treated wild-type mice
• mice exhibit reduced alternation in a Y-maze compared with wild-type mice
• mice exhibit reduced retention in a passive avoidance test compared with wild-type mice
• young, but not old, mice exhibit increased immobility during a forced swim test compared with wild-type mice
• old, but not young, mice exhibit an increase in startle amplitude compared with wild-type mice
• in young, but not old, mice exhibit increased activity in an open field test and entries in an elevated plus maze or Y-maze compared with wild-type mice
• at 9 months, mice exhibit slight hyperactivity compared with wild-type mice
• however, mice exhibit normal activity levels at 22 months
• amphetamine-treated mice exhibit increased hyperactivity compared with similarly treated wild-type mice

nervous system

cellular
• in CA1 of the hippocampus

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:157859





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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory