Mouse Genome Informatics
hm1
    Fbn2mz/Fbn2mz
involves: BALB/cAnNCrl * C3H/HeH
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Muscle weakness in Fbn2mz/Fbn2mz mice

muscle
• in the soleus muscle
• at 4 months, peak isometric tetanic force is higher than in wild-type muscle cells
• however, peak isometric stress is normal
• generalized

behavior/neurological
• mice exhibit poor performance in the MoRAG test for measuring grasping and retrieval of food pellets compared with wild-type mice
• in the grip strength and wire maneuver tests

limbs/digits/tail
• with two or more adjacent toes on the hind limb paw

growth/size/body

skeleton

Mouse Models of Human Disease
OMIM IDRef(s)
Arthrogryposis, Distal, Type 9; DA9 121050 J:157998


Mouse Genome Informatics
ht2
    Fbn2fp/Fbn2mz
involves: BALB/cAnNCrl * C3H/HeH * C3HeB/FeHu * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Limb clasping, reduced grip strength, and syndactyly in Fbn2mz/Fbn2mz, Fbn2fp/Fbn2fp and Fbn2mz/Fbn2fp mice

behavior/neurological

muscle