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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fbn2mz
mariusz
MGI:4438056
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fbn2mz/Fbn2mz involves: BALB/cAnNCrl * C3H/HeH MGI:4438065
ht2
Fbn2fp/Fbn2mz involves: BALB/cAnNCrl * C3H/HeH * C3HeB/FeHu * C57BL/6J MGI:4438066


Genotype
MGI:4438065
hm1
Allelic
Composition
Fbn2mz/Fbn2mz
Genetic
Background
involves: BALB/cAnNCrl * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn2mz mutation (0 available); any Fbn2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Muscle weakness in Fbn2mz/Fbn2mz mice

muscle
• in the soleus muscle
• at 4 months, peak isometric tetanic force is higher than in wild-type muscle cells
• however, peak isometric stress is normal
• generalized

behavior/neurological
• mice exhibit poor performance in the MoRAG test for measuring grasping and retrieval of food pellets compared with wild-type mice
• in the grip strength and wire maneuver tests

limbs/digits/tail
• with two or more adjacent toes on the hind limb paw

growth/size/body

skeleton

Mouse Models of Human Disease
OMIM ID Ref(s)
Arthrogryposis, Distal, Type 9; DA9 121050 J:157998




Genotype
MGI:4438066
ht2
Allelic
Composition
Fbn2fp/Fbn2mz
Genetic
Background
involves: BALB/cAnNCrl * C3H/HeH * C3HeB/FeHu * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn2fp mutation (1 available); any Fbn2 mutation (53 available)
Fbn2mz mutation (0 available); any Fbn2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Limb clasping, reduced grip strength, and syndactyly in Fbn2mz/Fbn2mz, Fbn2fp/Fbn2fp and Fbn2mz/Fbn2fp mice

behavior/neurological

muscle





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory