Mouse Genome Informatics
hm1
    Cryaatm1Ady/Cryaatm1Ady
involves: 129
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Lens opacity in Cryaatm1Ady/Cryaa+, Cryaatm1Ady/Cryaatm1Ady, and Cryaatm1.1Ady/Cryaatm1.1Ady mice

vision/eye
• at 3 months, mice exhibit rupture of the posterior capsule unlike wild-type mice
• at 3 weeks, lenses contain small and large swollen cells or vacuoles in the lens cortical fiber with gaps between fiber cells unlike in wild-type mice
• fiber cells detach from the capsule unlike in wild-type mice
• the number of swollen fiber cells increases with age
• at 10 months, large aberrant fibers cells are observed unlike in wild-type mice
• beginning prior to 2 months of age, near complete at 3 months of age, and complete at 5 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Cataract 9, Multiple Types; CTRCT9 604219 J:157274


Mouse Genome Informatics
ht2
    Cryaatm1Ady/Cryaa+
involves: 129
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Lens opacity in Cryaatm1Ady/Cryaa+, Cryaatm1Ady/Cryaatm1Ady, and Cryaatm1.1Ady/Cryaatm1.1Ady mice

vision/eye
• at 9 months, mice exhibit severe posterior rupture of the lens, curling up of the posterior capsule, and migration of cells to the posterior lens unlike wild-type mice
• at 9 months, mice exhibit severe posterior rupture of the lens unlike wild-type mice
• at 3 weeks, lenses contain small and large swollen cells or vacuoles in the lens cortical fiber unlike in wild-type mice
• beginning at 2 to 3 months of age and worsening with age in the posterior and nuclear regions of the lens

Mouse Models of Human Disease
OMIM IDRef(s)
Cataract 9, Multiple Types; CTRCT9 604219 J:157274