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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgf21tm1Emf
targeted mutation 1, Eleftheria Maratos-Flier
MGI:4436716
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fgf21tm1Emf/Fgf21tm1Emf B6.Cg-Fgf21tm1Emf MGI:4436717


Genotype
MGI:4436717
hm1
Allelic
Composition
Fgf21tm1Emf/Fgf21tm1Emf
Genetic
Background
B6.Cg-Fgf21tm1Emf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf21tm1Emf mutation (0 available); any Fgf21 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cold exposed mice exhibit reduced body temperatures, reduced activity and increased circulating creatine kinase activity levels compared with wild-type mice
• in ketogenetic diet fed mice
• in cold-exposed mice
• in the chow fed and fasted state, VO2 levels decreased
• in ketogenetic diet fed mice
• in ketogenetic diet fed mice
• markedly increased glucose excursion in response to an ip glucose load
• in the livers of mice fed a ketogenetic diet
• exhibit abnormal expression of genes regulating lipid homeostasis in adipose tissue
• in ketogenetic diet fed mice
• in ketogenetic diet fed mice
• decrease in the concentration of non-esterfied fatty acids in fasted mice
• 2 fold increase in mice fed a ketogenetic diet
• decreased levels of the liver ketoneogenesis enzyme beta-hydroxybutyrate in the blood of mice fed a ketogenetic diet
• in cold-exposed mice

adipose tissue
• when fed a ketogenetic diet for 14 days
• at 24 weeks of age
• longitudinal analysis of body composition reveals a marked increase in body fat content
• an increase in lipid stores in brown adipose tissue
• in perigonadal white adipose tissue
• significant elevation of perigonadal white adipose tissue when fed a ketogenetic diet for 14 days

liver/biliary system
• in the livers of mice fed a ketogenetic diet
• 2 fold increase in mice fed a ketogenetic diet
• significant elevation of liver weight when fed a ketogenetic diet for 14 days
• fatty appearance is reflected at a histological level with lipid accumulation encroaching across the hepatic lobule toward the central vein
• increase in liver glycogen in mice fed a ketogenetic diet

growth/size/body
• at 14 and 24 weeks of age
• fasting for 24 hours on leads to less weight loss
• at 24 weeks of age
• mice placed on a ketogenetic diet for 2 wk gain substantial weight, unlike wild-type mice that lose weight

behavior/neurological
• moderate increase in daily caloric intake of chow, even when corrected for the increased body weight mice on a ketogenetic diet have a greater caloric intake
• mice on a ketogenetic diet have lower physical activity (J:157309)
• in cold-exposed mice (J:181337)

nervous system
• hypothalamic neuropeptides revealed higher expression of proopiomelanocortin and lower expression of agouti- related peptide





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory