Phenotypes associated with this allele

• Allele Symbol: Dock10^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4436497
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock10^tm1a(EUCOMM)Hmgu/Dock10^tm1a(EUCOMM)Hmgu	C57BL/6N-Dock10^tm1a(EUCOMM)Hmgu/Ieg	MGI:5782061

Genotype
MGI:5782061

hm1

• Allelic Composition: Dock10^{tm1a(EUCOMM)Hmgu}/Dock10^{tm1a(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Dock10^{tm1a(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0551_3_C11

Data Sources

IMPC Data for Dock10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal thymus cell ratio ( J:238172 )

• decreased thymic CD8+ T cell percentage

arrested B cell differentiation ( J:236911 )

• B-cell developmental block in secondary lymphoid tissues

increased hematocrit ( J:165965 )

♂

IMPC - HMGU

decreased hemoglobin content ( J:165965 )

♀

IMPC - HMGU

increased hemoglobin content ( J:165965 )

♂

IMPC - HMGU

decreased B cell number ( J:236911 )

• significant reduction of CD19+ B cell numbers in spleen and peripheral blood, both in percentages and in absolute terms

decreased follicular B cell number ( J:236911 )

• significant reduction of CD21+ CD23+ follicular B cells in spleen

increased T cell number ( J:236911 )

• significant increase in percentages but not absolute numbers of CD3+ T cells in spleen and peripheral blood

increased single-positive T cell number ( J:236911 )

• significant increase in percentages but not absolute numbers of CD4+ and CD8+ subsets in spleen and peripheral blood

abnormal spleen marginal zone morphology ( J:238172 )

• narrowing of B cell region (B220+ region outside CD169+ MZ macrophages)

decreased marginal zone B cell number ( J:236911 )

• significant reduction of CD21+ CD23- marginal zone B cells in spleen, with increased ratio of CD23+ cells versus CD23- cells

abnormal B cell physiology ( J:236911 )

• CD23 is significantly overexpressed in peripheral blood B cells

• spleen B cells show normal migratory response to chemokines CXCL13 and CCL21 in vitro

• normal anti-apoptotic effect of IL-4 in vitro

abnormal follicular B cell physiology ( J:236911 )

• CD23 is significantly overexpressed on follicular B cells

• however, global mRNA levels of Fcer2a (which encodes CD23) are not altered

endocrine/exocrine glands

abnormal thymus cell ratio ( J:238172 )

• decreased thymic CD8+ T cell percentage

growth/size/body

growth/size/body region phenotype ( J:238172 )

N • no gross abnormalities

immune system

immune system phenotype ( J:238172 )

N • normal number of viable B and T cells in bone marrow, spleen, thymus and peritoneal cavity

N • normal percentage of B cells in spleen marginal zone

N • normal spleen and thymus histology

N • normal immune responses against NP-CGG, TNP-LPS and TNP-Ficoll

N • normal LPS-induced spleen marginal zone B cell proliferation

N • normal migration of spleen marginal zone B cells towards B lymphocyte chemoattractant (BLC) and SDF-1alpha

abnormal thymus cell ratio ( J:238172 )

• decreased thymic CD8+ T cell percentage

arrested B cell differentiation ( J:236911 )

• B-cell developmental block in secondary lymphoid tissues

decreased B cell number ( J:236911 )

• significant reduction of CD19+ B cell numbers in spleen and peripheral blood, both in percentages and in absolute terms

decreased follicular B cell number ( J:236911 )

• significant reduction of CD21+ CD23+ follicular B cells in spleen

increased T cell number ( J:236911 )

• significant increase in percentages but not absolute numbers of CD3+ T cells in spleen and peripheral blood

increased single-positive T cell number ( J:236911 )

• significant increase in percentages but not absolute numbers of CD4+ and CD8+ subsets in spleen and peripheral blood

abnormal spleen marginal zone morphology ( J:238172 )

• narrowing of B cell region (B220+ region outside CD169+ MZ macrophages)

decreased marginal zone B cell number ( J:236911 )

• significant reduction of CD21+ CD23- marginal zone B cells in spleen, with increased ratio of CD23+ cells versus CD23- cells

abnormal B cell physiology ( J:236911 )

• CD23 is significantly overexpressed in peripheral blood B cells

• spleen B cells show normal migratory response to chemokines CXCL13 and CCL21 in vitro

• normal anti-apoptotic effect of IL-4 in vitro

abnormal follicular B cell physiology ( J:236911 )

• CD23 is significantly overexpressed on follicular B cells

• however, global mRNA levels of Fcer2a (which encodes CD23) are not altered

behavior/neurological

abnormal behavior ( J:165965 )

IMPC - HMGU

mortality/aging

mortality/aging ( J:238172 )

N • viable

reproductive system

reproductive system phenotype ( J:238172 )

N • fertile