All Phenotypes Brpf1<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brpf1^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4433631

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6J * C57BL/6N	MGI:5896563
ht2	Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1⁺	involves: C57BL/6J * C57BL/6N	MGI:5896562
ht3	Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1⁺	Not Specified	MGI:5450498

Allelic Composition	Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6J * C57BL/6N
Cell Lines	EPD0069_1_G06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brpf1^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Brpf1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:222304 )

• homozygotes appear to die prior to E11.5

Allelic Composition	Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1⁺
Genetic Background	involves: C57BL/6J * C57BL/6N
Cell Lines	EPD0069_1_G06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brpf1^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Brpf1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:222304 )

• mice are rather indistinguishable from wild-type controls

Allelic Composition	Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1⁺
Genetic Background	Not Specified
Cell Lines	EPD0069_1_G06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brpf1^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Brpf1 mutation (37 available)

Data Sources

IMPC Data for Brpf1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:165965 )

IMPC - HAR

skeleton

decreased bone mineral density ( J:165965 )

IMPC - HAR

hematopoietic system

decreased T cell number ( J:165965 )

IMPC - HAR

increased monocyte cell number ( J:165965 )

IMPC - HAR

immune system

decreased T cell number ( J:165965 )

IMPC - HAR

increased monocyte cell number ( J:165965 )

IMPC - HAR

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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