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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lztr1tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4432946
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lztr1tm1a(EUCOMM)Wtsi/Lztr1tm1a(EUCOMM)Wtsi C57BL/6N-Lztr1tm1a(EUCOMM)Wtsi/Wtsi MGI:5631286
hm2
Lztr1tm1a(EUCOMM)Wtsi/Lztr1tm1a(EUCOMM)Wtsi involves: C57BL/6N MGI:6315870
ht3
Lztr1tm1a(EUCOMM)Wtsi/Lztr1+ C57BL/6N-Lztr1tm1a(EUCOMM)Wtsi/Wtsi MGI:5706035
ht4
Lztr1tm1a(EUCOMM)Wtsi/Lztr1+ involves: C57BL/6N MGI:6315869


Genotype
MGI:5631286
hm1
Allelic
Composition
Lztr1tm1a(EUCOMM)Wtsi/Lztr1tm1a(EUCOMM)Wtsi
Genetic
Background
C57BL/6N-Lztr1tm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0140_5_E07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lztr1tm1a(EUCOMM)Wtsi mutation (3 available); any Lztr1 mutation (10 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6315870
hm2
Allelic
Composition
Lztr1tm1a(EUCOMM)Wtsi/Lztr1tm1a(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lztr1tm1a(EUCOMM)Wtsi mutation (3 available); any Lztr1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lethal between E17.5 and birth
• pimasertib treatment rescues the lethality of homozygous mice




Genotype
MGI:5706035
ht3
Allelic
Composition
Lztr1tm1a(EUCOMM)Wtsi/Lztr1+
Genetic
Background
C57BL/6N-Lztr1tm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0140_5_E07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lztr1tm1a(EUCOMM)Wtsi mutation (3 available); any Lztr1 mutation (10 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial

growth/size/body

hematopoietic system

homeostasis/metabolism

skeleton




Genotype
MGI:6315869
ht4
Allelic
Composition
Lztr1tm1a(EUCOMM)Wtsi/Lztr1+
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lztr1tm1a(EUCOMM)Wtsi mutation (3 available); any Lztr1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit reduced longevity, with reduced survival beginning around 20 weeks of age

growth/size/body
• eccentric hypertrophy
• males exhibit facial dysmorphia
• males exhibit decreased weight

craniofacial
• shorter skull length in males
• increase in skull width
• decrease in parietal bone length
• increase in nasal bone width
• males exhibit facial dysmorphia

cardiovascular system
• increase in cardiomyocyte area
• eccentric hypertrophy
• increase in stroke volume in females
• decrease in % ejection fraction and fractional shortening in males
• echocardiography indicates decreased left ventricular systolic function and increased diastolic dimensions

cellular
• MEFs exhibit increased growth rate

muscle
• increase in cardiomyocyte area
• decrease in % ejection fraction and fractional shortening in males

skeleton
• shorter skull length in males
• increase in skull width
• decrease in parietal bone length
• increase in nasal bone width

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Noonan syndrome 10 DOID:0060588 OMIM:616564
J:268690





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory