Phenotypes associated with this allele

• Allele Symbol: Nxn^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432925
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nxn^tm1a(EUCOMM)Wtsi/Nxn^tm1a(EUCOMM)Wtsi	C57BL/6N-Nxn^tm1a(EUCOMM)Wtsi/Bay	MGI:5884020
ht2	Nxn^tm1a(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1a(EUCOMM)Wtsi/Bay	MGI:5884019
ht3	Nxn^tm1a(EUCOMM)Wtsi/Nxn^+	C57BL/6N-Nxn^tm1a(EUCOMM)Wtsi/Ieg	MGI:5782148

Genotype
MGI:5884020

hm1

• Allelic Composition: Nxn^{tm1a(EUCOMM)Wtsi}/Nxn^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nxn^{tm1a(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:5884019

ht2

• Allelic Composition: Nxn^{tm1a(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1a(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0045_1_A11

Data Sources

IMPC Data for Nxn

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - BCM

decreased cardiac muscle contractility ( J:211773 )

♀

IMPC - BCM

muscle

decreased cardiac muscle contractility ( J:211773 )

♀

IMPC - BCM

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - BCM

irregularly shaped pupil ( J:211773 )

♀

IMPC - BCM

anophthalmia ( J:211773 )

♀

IMPC - BCM

Genotype
MGI:5782148

ht3

• Allelic Composition: Nxn^{tm1a(EUCOMM)Wtsi}/Nxn⁺
• Genetic Background: C57BL/6N-Nxn^{tm1a(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0045_1_B11

Data Sources

IMPC Data for Nxn

behavior/neurological

increased grip strength ( J:165965 )

IMPC - HMGU