All Phenotypes Il4/Il13<tm1.1Lky> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il4/Il13^tm1.1Lky
targeted mutation 1.1, Richard M Locksley
MGI:4431368

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Il4/Il13^tm1.1Lky/Il4/Il13^tm1.1Lky Il4/Il13^tm1.1Lky/Il4/Il13^tm1.1Lky	involves: 129P2/OlaHsd * BALB/c	MGI:5301109

Allelic Composition	Il4/Il13^tm1.1Lky/Il4/Il13^tm1.1Lky Il4/Il13^tm1.1Lky/Il4/Il13^tm1.1Lky
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4/Il13^tm1.1Lky mutation (2 available); any Il4 mutation (42 available)
Il4/Il13^tm1.1Lky mutation (2 available); any Il13 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased susceptibility to weight loss ( J:178294 )

• mice lose weight during cold exposure

homeostasis/metabolism

decreased core body temperature ( J:178294 )

• drops when exposed to 4C

• core temperature improves when treated with a beta adrenergic agonist

decreased noradrenaline level ( J:178294 )

• noradrenaline content of adipose tissue is reduced 50-60% with cold exposure

decreased fatty acids level ( J:178294 )

• reduced circulating free fatty acids when exposed to 4C

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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