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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ripk3tm1Xidw
targeted mutation 1, Xiaodong Wang
MGI:4431195
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ripk3tm1Xidw/Ripk3tm1Xidw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4431201


Genotype
MGI:4431201
hm1
Allelic
Composition
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• cerulein-treated mice fail to exhibit pancreas acinar cell loss and necrosis unlike similarly treated wild-type mice

cellular
• Trail plus Smac-, TNF-a/Smac mimetic/z-VAD-, or TRAIL/Smac mimetic/z-VAD-treated mouse embryonic fibroblasts (MEFs) fail to undergo cell death (apoptosis or necrosis) unlike similarly treated wild-type mice
• however, MEFs undergo apoptosis following treatment with TNF-a plus cycloheximide





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory