Phenotypes associated with this allele

• Allele Symbol: Stk4^tm1.1Rjo
• Allele Name: targeted mutation 1.1, Randy L Johnson
• Allele ID: MGI:4430536
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stk3^tm1.1Rjo/Stk3^tm1.1Rjo Stk4^tm1.1Rjo/Stk4^tm1.1Rjo Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL	MGI:4430567

Genotype
MGI:4430567

cn1

• Allelic Composition: Stk3^tm1.1Rjo/Stk3^tm1.1Rjo; Stk4^tm1.1Rjo/Stk4^tm1.1Rjo; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased hepatocyte apoptosis ( J:156531 )

• modest increases in cell death of hepatocytes

increased hepatocyte proliferation ( J:156531 )

• increased proliferation index at 3 months of age as measure by elevated levels of BrdU incorporation

abnormal liver morphology ( J:156531 )

• at 2 months of age, large numbers of small periductal cells are visible that infiltrate the liver parenchyma

• at 3 months of age, small periductal cells surround the hepatic plates

abnormal liver sinusoid morphology ( J:156531 )

• an irregular arrangement of hepatocytes that obscures the normal radiating pattern of liver sinusoids

increased liver weight ( J:156531 )

• a 2-fold increase in liver mass relative to total body mass at 1 month of age and a 3-fold increase by 3 months of age

abnormal hepatocyte morphology ( J:156531 )

• hepatocytes exhibit a "clear cell" phenotype

increased liver tumor incidence ( J:156531 )

• tumors are detectable in some mice at 3 months of age and in all mice at 4 months of age

• livers are highly enlarged and have multiple focal tumors visible at 5-6 months of age

• disorganized parenchyma with the majority of the liver exhibiting a dysplastic partially transformed phenotype

increased hepatocellular carcinoma incidence ( J:156531 )

• the histopathology of tumor nodules is consistent with a diagnosis of hepatocellular carcinoma

neoplasm

increased liver tumor incidence ( J:156531 )

• tumors are detectable in some mice at 3 months of age and in all mice at 4 months of age

• livers are highly enlarged and have multiple focal tumors visible at 5-6 months of age

• disorganized parenchyma with the majority of the liver exhibiting a dysplastic partially transformed phenotype

increased hepatocellular carcinoma incidence ( J:156531 )

• the histopathology of tumor nodules is consistent with a diagnosis of hepatocellular carcinoma

cardiovascular system

abnormal liver sinusoid morphology ( J:156531 )

• an irregular arrangement of hepatocytes that obscures the normal radiating pattern of liver sinusoids

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:156531 )

N • despite morphological liver changes, no increase in serum alanine aminotransferase or aspartate aminotransferase levels are detected at 2 months of age

cellular

increased hepatocyte apoptosis ( J:156531 )

• modest increases in cell death of hepatocytes

increased hepatocyte proliferation ( J:156531 )

• increased proliferation index at 3 months of age as measure by elevated levels of BrdU incorporation

growth/size/body

increased liver weight ( J:156531 )

• a 2-fold increase in liver mass relative to total body mass at 1 month of age and a 3-fold increase by 3 months of age